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- W2893179994 abstract "Passive immunotherapy, i.e., the administration of exogenous antibodies that recognize a specific target antigen, has gained significant momentum as a potential treatment strategy for several central nervous system (CNS) disorders, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and brain cancer, among others. Advances in antibody engineering to create therapeutic antibody fragments or antibody conjugates have introduced new strategies that may also be applied to treat CNS disorders. However, drug delivery to the CNS for antibodies and other macromolecules has thus far proven challenging, due in large part to the blood-brain barrier and blood-cerebrospinal fluid barriers that greatly restrict transport of peripherally administered molecules from the systemic circulation into the CNS. Here, we summarize the various passive immunotherapy approaches under study for the treatment of CNS disorders, with a primary focus on disease-specific and target site-specific challenges to drug delivery and new, cutting edge methods." @default.
- W2893179994 created "2018-10-05" @default.
- W2893179994 creator A5004323167 @default.
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- W2893179994 creator A5024129257 @default.
- W2893179994 creator A5024928191 @default.
- W2893179994 creator A5055863552 @default.
- W2893179994 creator A5071217862 @default.
- W2893179994 date "2018-09-28" @default.
- W2893179994 modified "2023-10-14" @default.
- W2893179994 title "Passive Immunotherapies for Central Nervous System Disorders: Current Delivery Challenges and New Approaches" @default.
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