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• W2893181918 startingPage "4057" @default.
• W2893181918 abstract "The current study was designed to investigate the effects and underlying mechanisms of adipose tissue-derived stem cells (ADSCs) on hypertrophic scar (HS) fibrosis.Real-time quantitative polymerase chain reaction (qRT-PCR) and Western blot analysis were performed to detect the expression of collagen I (Col1), collagen III (Col3), and α-smooth muscle actin (α-SMA) after fibroblasts and cultured HS tissues were treated with ADSC medium. All data were analyzed by using SPSS17.0 software. Statistical analysis was performed by Student t tests.The in vitro study showed that ADSC medium decreased the expression of Col1, Col3, and α-SMA. In addition, the protein level of p-p38 was downregulated by ADSC medium treatment in a concentration dependent manner.The current study demonstrated that ADSC could decrease collagen deposition and scar formation in in vitro experiments. The regulation of the p38/MAPK signaling pathway might play an important role in the process." @default.
• W2893181918 created "2018-10-05" @default.
• W2893181918 creator A5021007375 @default.
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• W2893181918 date "2018-09-27" @default.
• W2893181918 modified "2023-09-24" @default.
• W2893181918 title "Adipose tissue‐derived stem cells inhibit hypertrophic scar (HS) fibrosis via p38/MAPK pathway" @default.
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• W2893181918 doi "https://doi.org/10.1002/jcb.27689" @default.
• W2893181918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30260015" @default.
• W2893181918 hasPublicationYear "2018" @default.
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