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• W2893184302 abstract "Significance Coordinated epithelial cell migration is key to maintaining functional integrity and preventing pathological processes in gastrointestinal tissue, and is essential for astronauts’ health and space mission success. Here we show that energetic heavy ions, which are more prevalent in deep space relative to low-Earth orbit, could persistently decrease intestinal epithelial cell migration, alter cytoskeletal remodeling, and increase cell proliferation with ongoing DNA damage and cell senescence, even a year after irradiation. Our study has provided the molecular underpinnings for energetic heavy-ion 56 Fe radiation-induced cell migration alterations, and raises a potentially serious concern, particularly for long-term deep-space manned missions." @default.
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• W2893184302 date "2018-10-01" @default.
• W2893184302 modified "2023-09-25" @default.
• W2893184302 title "Space radiation triggers persistent stress response, increases senescent signaling, and decreases cell migration in mouse intestine" @default.
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• W2893184302 doi "https://doi.org/10.1073/pnas.1807522115" @default.
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