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- W2893190213 abstract "Abstract Peroxynitrite (ONOO−) is an important kind of reactive oxygen species (ROS), played an essential role in physiology and pathology. To date, various fluorescent probes for ONOO− have been constructed successfully, but these probes exhibit turn-on fluorescence signal in single channel. While, ratiometric fluorescent probes, especially those probes with large emission shift, are suitable for bioimage in two channels. Herein, a hemicyanine-based fluorescent probe named Cy-NH2 was designed and synthesized for ratiometric detection of ONOO−. The characteristics of Cy-NH2 are as follows: (1) The probe possesses a simple structure, which can be obtained by easy synthetic steps; (2) The ratiometric fluorescent probe owns large emission shift (248 nm) due to the disruption of π-conjugation system caused by strong oxidizing ability of ONOO−; (3) The probe exhibits high sensitivity to ONOO− with 1728-fold enhancement of fluorescence intensity ratio and superior selectivity for ONOO− over various potentially interfering biological analytes; (4) The ratiometric fluorescent probe is applied for the image detection of exogenous and endogenous ONOO− in living cells successfully." @default.
- W2893190213 created "2018-10-05" @default.
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- W2893190213 date "2019-02-01" @default.
- W2893190213 modified "2023-09-24" @default.
- W2893190213 title "A ratiometric fluorescent probe for the detection of peroxynitrite with simple synthesis and large emission shift and its application in cells image" @default.
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- W2893190213 doi "https://doi.org/10.1016/j.dyepig.2018.09.059" @default.
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