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• W2893198872 abstract "Long noncoding RNA (lncRNA) H19 is abundantly expressed in fetal liver. Its expression is significantly diminished in adult healthy liver but is re-induced in chronic liver diseases, including cholestasis. In this study, we developed a new method with combined in situ hybridization (ISH) and immunofluorescence (IF) colabeling to establish an H19 expression profile with both parenchymal and nonparenchymal cell-specific markers in the livers of cholestatic mouse models and patients with cholestasis. H19 RNA + cells showed no colocalization with biliary epithelial cell marker cytokeratin 19 (CK19) + cholangiocytes but were immediately adjacent to biliary structures in bile duct ligation (BDL), 3,5-diethoxycarbony1-1,4-dihydrocollidine (DDC), and multidrug-resistant gene 2 knockout ( Mdr2 –/– ) mouse models and in human primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) liver specimens. In contrast, double-positive H19 RNA + /sex-determining region Y (SRY)-box 9 (SOX9) + ductal progenitor cells, H19 RNA + /hepatocyte nuclear factor 4α (HNF4α) + hepatocytes, H19 RNA + /F4/80 + Kupffer cells, HNF4α + /SOX9 + hybrid hepatocytes, as well as triple-positive H19 RNA + /HNF4α + /SOX9 + periportal hepatocytes were identified. In addition, H19 RNA could not be detected in mesenchymal cell marker desmin + cells. Furthermore, H19 RNA was predominately detected in cytoplasm with a small amount at the interspace with neighboring cells. Conclusion: H19 RNA is localized in HNF4α + periportal hepatocytes, SOX9 + ductal progenitor cells, and F4/80 + Kupffer cells but not in CK19 + cholangiocytes and desmin + stellate cells in cholestatic livers. H19RNA-labeled periportal hepatocytes may represent a new subpopulation of resident stem/progenitor cells. Its lack of expression in cholangiocytes suggests it may act as a paracrine signaling by secretion from nearby cells." @default.
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• W2893198872 date "2018-11-01" @default.
• W2893198872 modified "2023-10-17" @default.
• W2893198872 title "H19 Is Expressed in Hybrid Hepatocyte Nuclear Factor 4α+ Periportal Hepatocytes but Not Cytokeratin 19+ Cholangiocytes in Cholestatic Livers" @default.
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• W2893198872 doi "https://doi.org/10.1002/hep4.1252" @default.
• W2893198872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6211330" @default.
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