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- W2893201325 abstract "Given the heterogeneity within depression, in this study we aim to examine how resting-state functional connectivity (RSFC) in adolescents is related to anhedonia and depression severity on a continuum in line with the research domain criteria (RDoC) approach.We examined how RSFC in the dorsal medial prefrontal cortex (dmPFC), nucleus accumbens (NAcc) and pregenual anterior cingulate cortex (pgACC) was related to anhedonia and depression severity in 86 adolescents (13-21 years).We found both anhedonia and depression severity related to decreased dmPFC RSFC with the precuneus, a part of the default mode network. However we also found that increased dmPFC connectivity with the ACC/paracingulate gyrus related to anhedonia whereas increased RSFC with the frontal pole related to depression severity.This work extends the view that the dmPFC is a potential therapeutic target for depression in two ways: 1. We report dmPFC connectivity in adolescents; and 2. We show different dmPFC RSFC specific to anhedonia and depression severity, providing neural targets for intervention in young people at risk of depression." @default.
- W2893201325 created "2018-10-05" @default.
- W2893201325 creator A5064050257 @default.
- W2893201325 creator A5085999805 @default.
- W2893201325 date "2018-09-27" @default.
- W2893201325 modified "2023-10-16" @default.
- W2893201325 title "Anhedonia and depression severity dissociated by dmPFC resting-state functional connectivity in adolescents" @default.
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- W2893201325 doi "https://doi.org/10.1177/0269881118799935" @default.
- W2893201325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6380625" @default.
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- W2893201325 hasPublicationYear "2018" @default.
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