Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893201630> ?p ?o ?g. }
- W2893201630 endingPage "525" @default.
- W2893201630 startingPage "525" @default.
- W2893201630 abstract "During bovine herpesvirus 1 (BoHV-1) productive infection in cell cultures, partial of intranuclear viral DNA is present in nucleosomes, and viral protein VP22 associates with histones and decreases histone H4 acetylation, indicating the involvement of histone H4 acetylation in virus replication. In this study, we demonstrated that BoHV-1 infection at the late stage (at 24 h after infection) dramatically decreased histone H3 acetylation [at residues K9 (H3K9ac) and K18 (H3K18ac)], which was supported by the pronounced depletion of histone acetyltransferases (HATs) including CBP/P300 (CREB binding protein and p300), GCN5L2 (general control of amino acid synthesis yeast homolog like 2) and PCAF (P300/CBP-associated factor). The depletion of GCN5L2 promoted by virus infection was partially mediated by ubiquitin-proteasome pathway. Interestingly, the viral replication was enhanced by HAT (histone acetyltransferase) activator CTPB [N-(4-Chloro-3-trifluoromethylphenyl)-2-ethoxy-6-pentadecylbenzamide], and vice versa, inhibited by HAT inhibitor Anacardic acid (AA), suggesting that BoHV-1 may take advantage of histone acetylation for efficient replication. Taken together, we proposed that the HAT-dependent histone H3 acetylation plays an important role in BoHV-1 replication in MDBK (Madin-Darby bovine kidney) cells." @default.
- W2893201630 created "2018-10-05" @default.
- W2893201630 creator A5032538237 @default.
- W2893201630 creator A5035845710 @default.
- W2893201630 creator A5037647101 @default.
- W2893201630 creator A5047928485 @default.
- W2893201630 creator A5074078977 @default.
- W2893201630 date "2018-09-27" @default.
- W2893201630 modified "2023-10-10" @default.
- W2893201630 title "The Involvement of Histone H3 Acetylation in Bovine Herpesvirus 1 Replication in MDBK Cells" @default.
- W2893201630 cites W1510086001 @default.
- W2893201630 cites W1536662766 @default.
- W2893201630 cites W1561945694 @default.
- W2893201630 cites W1897662255 @default.
- W2893201630 cites W1971139038 @default.
- W2893201630 cites W1972289746 @default.
- W2893201630 cites W1976933461 @default.
- W2893201630 cites W1978199134 @default.
- W2893201630 cites W1978726512 @default.
- W2893201630 cites W1983861034 @default.
- W2893201630 cites W1989429514 @default.
- W2893201630 cites W2001476460 @default.
- W2893201630 cites W2008099851 @default.
- W2893201630 cites W2008435997 @default.
- W2893201630 cites W2010657765 @default.
- W2893201630 cites W2011285661 @default.
- W2893201630 cites W2013571070 @default.
- W2893201630 cites W2022936129 @default.
- W2893201630 cites W2024824043 @default.
- W2893201630 cites W2047881988 @default.
- W2893201630 cites W2054696920 @default.
- W2893201630 cites W2057511703 @default.
- W2893201630 cites W2100070253 @default.
- W2893201630 cites W2105240882 @default.
- W2893201630 cites W2114906848 @default.
- W2893201630 cites W2117877312 @default.
- W2893201630 cites W2118600936 @default.
- W2893201630 cites W2132351720 @default.
- W2893201630 cites W2136623765 @default.
- W2893201630 cites W2143716699 @default.
- W2893201630 cites W2143988903 @default.
- W2893201630 cites W2144526193 @default.
- W2893201630 cites W2147524392 @default.
- W2893201630 cites W2150960435 @default.
- W2893201630 cites W2154153723 @default.
- W2893201630 cites W2163746227 @default.
- W2893201630 cites W2168465652 @default.
- W2893201630 cites W2172177489 @default.
- W2893201630 cites W2201987966 @default.
- W2893201630 cites W2274048361 @default.
- W2893201630 cites W2306286459 @default.
- W2893201630 cites W2313682627 @default.
- W2893201630 cites W2335853993 @default.
- W2893201630 cites W2589274998 @default.
- W2893201630 cites W2725774413 @default.
- W2893201630 cites W2734420271 @default.
- W2893201630 cites W2751361662 @default.
- W2893201630 cites W2762380555 @default.
- W2893201630 cites W2772087653 @default.
- W2893201630 doi "https://doi.org/10.3390/v10100525" @default.
- W2893201630 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6213513" @default.
- W2893201630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30261679" @default.
- W2893201630 hasPublicationYear "2018" @default.
- W2893201630 type Work @default.
- W2893201630 sameAs 2893201630 @default.
- W2893201630 citedByCount "6" @default.
- W2893201630 countsByYear W28932016302019 @default.
- W2893201630 countsByYear W28932016302020 @default.
- W2893201630 countsByYear W28932016302021 @default.
- W2893201630 crossrefType "journal-article" @default.
- W2893201630 hasAuthorship W2893201630A5032538237 @default.
- W2893201630 hasAuthorship W2893201630A5035845710 @default.
- W2893201630 hasAuthorship W2893201630A5037647101 @default.
- W2893201630 hasAuthorship W2893201630A5047928485 @default.
- W2893201630 hasAuthorship W2893201630A5074078977 @default.
- W2893201630 hasBestOaLocation W28932016301 @default.
- W2893201630 hasConcept C104317684 @default.
- W2893201630 hasConcept C107793267 @default.
- W2893201630 hasConcept C119157956 @default.
- W2893201630 hasConcept C150425827 @default.
- W2893201630 hasConcept C153911025 @default.
- W2893201630 hasConcept C173681060 @default.
- W2893201630 hasConcept C2776745794 @default.
- W2893201630 hasConcept C2778001298 @default.
- W2893201630 hasConcept C2778305200 @default.
- W2893201630 hasConcept C2779085176 @default.
- W2893201630 hasConcept C2910921701 @default.
- W2893201630 hasConcept C45946802 @default.
- W2893201630 hasConcept C552990157 @default.
- W2893201630 hasConcept C55493867 @default.
- W2893201630 hasConcept C56428682 @default.
- W2893201630 hasConcept C58793620 @default.
- W2893201630 hasConcept C64927066 @default.
- W2893201630 hasConcept C71723506 @default.
- W2893201630 hasConcept C84772758 @default.
- W2893201630 hasConcept C86803240 @default.
- W2893201630 hasConceptScore W2893201630C104317684 @default.
- W2893201630 hasConceptScore W2893201630C107793267 @default.