Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893205963> ?p ?o ?g. }
- W2893205963 endingPage "2932" @default.
- W2893205963 startingPage "2932" @default.
- W2893205963 abstract "Non-alcoholic fatty liver disease (NAFLD) is characterized by ectopic lipid accumulation in the liver, usually combined with hepatic insulin resistance. Fc-gamma receptor-IIb (FcγRIIb) and its ligand are reported to be associated with obesity and type 2 diabetes mellitus (T2DM). As knowledge about FcγRIIb in the literature is mostly generated from studies on skeletal muscle tissue, the expression and function of FcγRIIb in the liver and hepatocytes are largely unknown. In this study, we identified the expression of FcγRIIb in primary cultured mouse hepatocytes: FcγRIIb was upregulated in response to oleic acid (OA) in a dose dependent manner. FcγRIIb knockdown using shRNA suppressed the lipid and triglyceride accumulation, and mRNA expression of ACC1, FASn, CD36, MTTP, and ApoB in OA-treated HepG2 cells. FcγRIIb deficiency mice fed with high fat diet (HFD) had significantly lower liver weight and liver to body weight ratio, as well as less triglyceride accumulation in the livers. In glycometabolism, FcγRIIb hindered insulin-induced phosphorylation of AKT and FOXO1, and in turn upregulated G6Pase and PEPCK mRNA expression, suggesting that FcγRIIb promotes gluconeogenesis by suppressing the AKT/FOXO1/G6Pase/PEPCK pathway in hepatocytes. This study reveals a novel role for FcγRIIb in regulating lipid metabolism and glycometabolism, and provides a new therapeutic target to improve NAFLD." @default.
- W2893205963 created "2018-10-05" @default.
- W2893205963 creator A5008962520 @default.
- W2893205963 creator A5012335867 @default.
- W2893205963 creator A5013074988 @default.
- W2893205963 creator A5032564870 @default.
- W2893205963 creator A5037677450 @default.
- W2893205963 creator A5083485575 @default.
- W2893205963 date "2018-09-26" @default.
- W2893205963 modified "2023-09-25" @default.
- W2893205963 title "Fc Gamma Receptor IIb Expressed in Hepatocytes Promotes Lipid Accumulation and Gluconeogenesis" @default.
- W2893205963 cites W1974744093 @default.
- W2893205963 cites W1995040522 @default.
- W2893205963 cites W2002496843 @default.
- W2893205963 cites W2020984495 @default.
- W2893205963 cites W2054943022 @default.
- W2893205963 cites W2065612971 @default.
- W2893205963 cites W2095576943 @default.
- W2893205963 cites W2098012175 @default.
- W2893205963 cites W2113106012 @default.
- W2893205963 cites W2133841841 @default.
- W2893205963 cites W2139856782 @default.
- W2893205963 cites W2142750712 @default.
- W2893205963 cites W2162382402 @default.
- W2893205963 cites W2165411190 @default.
- W2893205963 cites W2204688218 @default.
- W2893205963 cites W2214603638 @default.
- W2893205963 cites W2230222215 @default.
- W2893205963 cites W2329728403 @default.
- W2893205963 cites W2343241386 @default.
- W2893205963 cites W2530564279 @default.
- W2893205963 cites W2743291282 @default.
- W2893205963 cites W2752428556 @default.
- W2893205963 cites W2770941844 @default.
- W2893205963 doi "https://doi.org/10.3390/ijms19102932" @default.
- W2893205963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6213401" @default.
- W2893205963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30261661" @default.
- W2893205963 hasPublicationYear "2018" @default.
- W2893205963 type Work @default.
- W2893205963 sameAs 2893205963 @default.
- W2893205963 citedByCount "7" @default.
- W2893205963 countsByYear W28932059632020 @default.
- W2893205963 countsByYear W28932059632021 @default.
- W2893205963 countsByYear W28932059632022 @default.
- W2893205963 countsByYear W28932059632023 @default.
- W2893205963 crossrefType "journal-article" @default.
- W2893205963 hasAuthorship W2893205963A5008962520 @default.
- W2893205963 hasAuthorship W2893205963A5012335867 @default.
- W2893205963 hasAuthorship W2893205963A5013074988 @default.
- W2893205963 hasAuthorship W2893205963A5032564870 @default.
- W2893205963 hasAuthorship W2893205963A5037677450 @default.
- W2893205963 hasAuthorship W2893205963A5083485575 @default.
- W2893205963 hasBestOaLocation W28932059631 @default.
- W2893205963 hasConcept C104317684 @default.
- W2893205963 hasConcept C112446052 @default.
- W2893205963 hasConcept C126322002 @default.
- W2893205963 hasConcept C127561419 @default.
- W2893205963 hasConcept C134018914 @default.
- W2893205963 hasConcept C140149449 @default.
- W2893205963 hasConcept C170493617 @default.
- W2893205963 hasConcept C185592680 @default.
- W2893205963 hasConcept C202751555 @default.
- W2893205963 hasConcept C20904676 @default.
- W2893205963 hasConcept C2776175330 @default.
- W2893205963 hasConcept C2776200302 @default.
- W2893205963 hasConcept C2777391703 @default.
- W2893205963 hasConcept C2778772119 @default.
- W2893205963 hasConcept C2779134260 @default.
- W2893205963 hasConcept C2779306644 @default.
- W2893205963 hasConcept C2779828298 @default.
- W2893205963 hasConcept C4733338 @default.
- W2893205963 hasConcept C55493867 @default.
- W2893205963 hasConcept C62231903 @default.
- W2893205963 hasConcept C62478195 @default.
- W2893205963 hasConcept C71924100 @default.
- W2893205963 hasConcept C75217442 @default.
- W2893205963 hasConcept C86803240 @default.
- W2893205963 hasConcept C95444343 @default.
- W2893205963 hasConceptScore W2893205963C104317684 @default.
- W2893205963 hasConceptScore W2893205963C112446052 @default.
- W2893205963 hasConceptScore W2893205963C126322002 @default.
- W2893205963 hasConceptScore W2893205963C127561419 @default.
- W2893205963 hasConceptScore W2893205963C134018914 @default.
- W2893205963 hasConceptScore W2893205963C140149449 @default.
- W2893205963 hasConceptScore W2893205963C170493617 @default.
- W2893205963 hasConceptScore W2893205963C185592680 @default.
- W2893205963 hasConceptScore W2893205963C202751555 @default.
- W2893205963 hasConceptScore W2893205963C20904676 @default.
- W2893205963 hasConceptScore W2893205963C2776175330 @default.
- W2893205963 hasConceptScore W2893205963C2776200302 @default.
- W2893205963 hasConceptScore W2893205963C2777391703 @default.
- W2893205963 hasConceptScore W2893205963C2778772119 @default.
- W2893205963 hasConceptScore W2893205963C2779134260 @default.
- W2893205963 hasConceptScore W2893205963C2779306644 @default.
- W2893205963 hasConceptScore W2893205963C2779828298 @default.
- W2893205963 hasConceptScore W2893205963C4733338 @default.
- W2893205963 hasConceptScore W2893205963C55493867 @default.
- W2893205963 hasConceptScore W2893205963C62231903 @default.