FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893205981> ?p ?o ?g. }

• W2893205981 abstract "A limited number of medications are approved to treat Alcohol Use Disorder (AUD). Furthermore, the magnitude of their therapeutic effect is relatively modest, suggesting the potential for subtypes of patients who respond to a specific medication. The use of these medications is also limited in clinical practice by a series of contraindications such as medical comorbidities and/or concurrent use of other medications. In recent years, animal and human studies have been conducted to evaluate the efficacy of baclofen, a GABAB receptor agonist approved for clinical use as a muscle relaxant, in the treatment of AUD. However, these studies have yielded contrasting results. Despite this discrepancy, baclofen is often used off-label to treat AUD, especially in some European countries and Australia. Recently, several factors have been considered to try to shed light on the potential reasons and mechanisms underlying the inconsistent results obtained until now. The presence of a psychiatric comorbidity may be amongst the abovementioned factors playing a role in explaining different responses to baclofen treatment in terms of alcohol drinking outcomes. Therefore, the aim here was to conduct a narrative review of the scientific literature related to the use of baclofen in AUD, both in patients with and without concomitant psychiatric disorders. All clinical studies (randomized and controlled, open-label, retrospective, human laboratory studies, and case reports) were analyzed and discussed, bearing in mind other potential factors that may have influenced baclofen response, including dose administered, severity of AUD, use of other psychosocial therapies, and the presence of physical disorders. This review indicates that the most frequent psychiatric comorbidities in patients affected by AUD undergoing baclofen treatment are anxiety and mood disorders. Unfortunately, no definitive conclusions can be drawn due to the lack of specific analyses on whether baclofen efficacy is different in AUD patients with comorbid psychiatric disorders vs. those without. Therefore, it will be critical that psychiatric comorbidities are considered in the planning of future studies and in the analysis of the data, with the ultimate goal of understanding whether subtypes of AUD patients may respond best to baclofen." @default.
• W2893205981 created "2018-10-05" @default.
• W2893205981 creator A5038660835 @default.
• W2893205981 creator A5091119332 @default.
• W2893205981 date "2018-09-28" @default.
• W2893205981 modified "2023-10-16" @default.
• W2893205981 title "Baclofen in the Treatment of Patients With Alcohol Use Disorder and Other Mental Health Disorders" @default.
• W2893205981 cites W1531838059 @default.
• W2893205981 cites W1617145133 @default.
• W2893205981 cites W1656795649 @default.
• W2893205981 cites W1752388475 @default.
• W2893205981 cites W1839921965 @default.
• W2893205981 cites W1965464464 @default.
• W2893205981 cites W1968136845 @default.
• W2893205981 cites W1975512870 @default.
• W2893205981 cites W1978189542 @default.
• W2893205981 cites W1998776321 @default.
• W2893205981 cites W2018861453 @default.
• W2893205981 cites W2030868346 @default.
• W2893205981 cites W2031918347 @default.
• W2893205981 cites W2035839366 @default.
• W2893205981 cites W2039251119 @default.
• W2893205981 cites W2041598613 @default.
• W2893205981 cites W2057807775 @default.
• W2893205981 cites W2077241399 @default.
• W2893205981 cites W2078594409 @default.
• W2893205981 cites W2081884761 @default.
• W2893205981 cites W2086175717 @default.
• W2893205981 cites W2104753186 @default.
• W2893205981 cites W2115147032 @default.
• W2893205981 cites W2123587439 @default.
• W2893205981 cites W2125995400 @default.
• W2893205981 cites W2127279273 @default.
• W2893205981 cites W2136006910 @default.
• W2893205981 cites W2136475835 @default.
• W2893205981 cites W2143264814 @default.
• W2893205981 cites W2145176659 @default.
• W2893205981 cites W2148232713 @default.
• W2893205981 cites W2149660440 @default.
• W2893205981 cites W2156044731 @default.
• W2893205981 cites W2162218546 @default.
• W2893205981 cites W2162363996 @default.
• W2893205981 cites W2170979974 @default.
• W2893205981 cites W2172137255 @default.
• W2893205981 cites W2200958456 @default.
• W2893205981 cites W2316913643 @default.
• W2893205981 cites W2335531868 @default.
• W2893205981 cites W2341739607 @default.
• W2893205981 cites W2400828834 @default.
• W2893205981 cites W2528385426 @default.
• W2893205981 cites W2546777102 @default.
• W2893205981 cites W2552950400 @default.
• W2893205981 cites W2562925864 @default.
• W2893205981 cites W2563607206 @default.
• W2893205981 cites W2565728627 @default.
• W2893205981 cites W2565896462 @default.
• W2893205981 cites W2588013903 @default.
• W2893205981 cites W2591409324 @default.
• W2893205981 cites W2608494439 @default.
• W2893205981 cites W2612744645 @default.
• W2893205981 cites W2615387563 @default.
• W2893205981 cites W2618648733 @default.
• W2893205981 cites W2732821476 @default.
• W2893205981 cites W2738473792 @default.
• W2893205981 cites W2782063084 @default.
• W2893205981 cites W2782206210 @default.
• W2893205981 cites W2782305149 @default.
• W2893205981 cites W2790977371 @default.
• W2893205981 cites W2793489992 @default.
• W2893205981 cites W2801922112 @default.
• W2893205981 cites W2802163639 @default.
• W2893205981 cites W2807948330 @default.
• W2893205981 cites W2809575156 @default.
• W2893205981 doi "https://doi.org/10.3389/fpsyt.2018.00464" @default.
• W2893205981 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6172346" @default.
• W2893205981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30323774" @default.
• W2893205981 hasPublicationYear "2018" @default.
• W2893205981 type Work @default.
• W2893205981 sameAs 2893205981 @default.
• W2893205981 citedByCount "20" @default.
• W2893205981 countsByYear W28932059812019 @default.
• W2893205981 countsByYear W28932059812020 @default.
• W2893205981 countsByYear W28932059812021 @default.
• W2893205981 countsByYear W28932059812022 @default.
• W2893205981 countsByYear W28932059812023 @default.
• W2893205981 crossrefType "journal-article" @default.
• W2893205981 hasAuthorship W2893205981A5038660835 @default.
• W2893205981 hasAuthorship W2893205981A5091119332 @default.
• W2893205981 hasBestOaLocation W28932059811 @default.
• W2893205981 hasConcept C118552586 @default.
• W2893205981 hasConcept C126322002 @default.
• W2893205981 hasConcept C134362201 @default.
• W2893205981 hasConcept C15744967 @default.
• W2893205981 hasConcept C170493617 @default.
• W2893205981 hasConcept C185592680 @default.
• W2893205981 hasConcept C2778938600 @default.
• W2893205981 hasConcept C2779442783 @default.
• W2893205981 hasConcept C2781066024 @default.
• W2893205981 hasConcept C2781201050 @default.
• W2893205981 hasConcept C542102704 @default.

• next