FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893208286> ?p ?o ?g. }

• W2893208286 endingPage "1197" @default.
• W2893208286 startingPage "1187" @default.
• W2893208286 abstract "The effect of Cannabis sativa extract on chemical kindling induced in rats by the repeated intraperitoneal (ip) injections of pentylenetetrazole (PTZ) was studied. Rats were treated with PTZ (35 mg/kg) once every 48 hours for 12 times alone or with ip Cannabis sativa (20 mg/kg expressed as Δ9-THC content) 30 min prior to PTZ injection. Seizures were recorded for 20 minutes. Control rats received ip saline. Cannabis treatment caused significant elevation of mean seizure score as compared to PTZ only group after the 5th, 6th and 7th PTZ repeated injections during seizure development. In particular, cannabis caused significant elevation in the frequency of myoclonic jerks, rearing (stage 3), turn over onto one side position and back position (stage 4), and generalized tonic-clonic seizures (stage 5) compared with the PTZ only group. PTZ caused significant elevations in brain lipid peroxidation (malondialdehyde), and nitric oxide along with deceased reduced glutathione level. In addition, brain acetylcholinesterase (AChE) activity significantly decreased compared to control value after PTZ treatment. Cannabis given to PTZ treated rats caused significant increase in brain malondialdehyde and AChE activity compared to PTZ only group. Reduced glutathione level was restored by cannabis. Histopathological studies indicated the presence of spongiform changes, degenerated and necrotic neurons, inflammatory cells, and gliosis in cerebral cortex and degeneration of some Purkinje cells in the cerebellum in both PTZ- and cannabis-PTZ-treated groups. It is concluded that in an epilepsy model induced by repeated PTZ administration, cannabis increased lipid peroxidation and mean seizure score." @default.
• W2893208286 created "2018-10-05" @default.
• W2893208286 creator A5013392061 @default.
• W2893208286 creator A5027814734 @default.
• W2893208286 creator A5061969917 @default.
• W2893208286 creator A5075246930 @default.
• W2893208286 creator A5083649051 @default.
• W2893208286 date "2018-09-15" @default.
• W2893208286 modified "2023-09-23" @default.
• W2893208286 title "Cannabis sativa Increases Seizure Severity and Brain Lipid Peroxidation in Pentylenetetrazole-Induced Kindling in Rats" @default.
• W2893208286 cites W116080739 @default.
• W2893208286 cites W1539201620 @default.
• W2893208286 cites W1684343866 @default.
• W2893208286 cites W1786879564 @default.
• W2893208286 cites W1875008998 @default.
• W2893208286 cites W1891967301 @default.
• W2893208286 cites W1898835919 @default.
• W2893208286 cites W1911127399 @default.
• W2893208286 cites W1947666932 @default.
• W2893208286 cites W1971048984 @default.
• W2893208286 cites W1974564599 @default.
• W2893208286 cites W1982457403 @default.
• W2893208286 cites W1992998321 @default.
• W2893208286 cites W1997059788 @default.
• W2893208286 cites W2002617050 @default.
• W2893208286 cites W2004792176 @default.
• W2893208286 cites W2005457679 @default.
• W2893208286 cites W2006370393 @default.
• W2893208286 cites W2008667918 @default.
• W2893208286 cites W2010440371 @default.
• W2893208286 cites W2013542706 @default.
• W2893208286 cites W2015318004 @default.
• W2893208286 cites W2020825180 @default.
• W2893208286 cites W2022686008 @default.
• W2893208286 cites W2022927857 @default.
• W2893208286 cites W2024304940 @default.
• W2893208286 cites W2029549580 @default.
• W2893208286 cites W2029764497 @default.
• W2893208286 cites W2036098732 @default.
• W2893208286 cites W2036959786 @default.
• W2893208286 cites W2039963755 @default.
• W2893208286 cites W2040927701 @default.
• W2893208286 cites W2040970496 @default.
• W2893208286 cites W2041923180 @default.
• W2893208286 cites W2051002047 @default.
• W2893208286 cites W2054140892 @default.
• W2893208286 cites W2059421922 @default.
• W2893208286 cites W2060130819 @default.
• W2893208286 cites W2069379969 @default.
• W2893208286 cites W2070046033 @default.
• W2893208286 cites W2082082322 @default.
• W2893208286 cites W2088105132 @default.
• W2893208286 cites W2095004045 @default.
• W2893208286 cites W2114062911 @default.
• W2893208286 cites W2115027782 @default.
• W2893208286 cites W2119499412 @default.
• W2893208286 cites W2141521344 @default.
• W2893208286 cites W2156311335 @default.
• W2893208286 cites W2156810428 @default.
• W2893208286 cites W2168111104 @default.
• W2893208286 cites W2169714384 @default.
• W2893208286 cites W2189806591 @default.
• W2893208286 cites W2264529879 @default.
• W2893208286 cites W2461566020 @default.
• W2893208286 cites W2483309513 @default.
• W2893208286 cites W2533929786 @default.
• W2893208286 cites W2535730691 @default.
• W2893208286 cites W2565318735 @default.
• W2893208286 cites W2580334864 @default.
• W2893208286 cites W2582140652 @default.
• W2893208286 cites W2753641668 @default.
• W2893208286 cites W2769621691 @default.
• W2893208286 cites W4229557966 @default.
• W2893208286 cites W4239151701 @default.
• W2893208286 cites W4244545050 @default.
• W2893208286 doi "https://doi.org/10.13005/bpj/1480" @default.
• W2893208286 hasPublicationYear "2018" @default.
• W2893208286 type Work @default.
• W2893208286 sameAs 2893208286 @default.
• W2893208286 citedByCount "8" @default.
• W2893208286 countsByYear W28932082862019 @default.
• W2893208286 countsByYear W28932082862020 @default.
• W2893208286 countsByYear W28932082862021 @default.
• W2893208286 countsByYear W28932082862022 @default.
• W2893208286 crossrefType "journal-article" @default.
• W2893208286 hasAuthorship W2893208286A5013392061 @default.
• W2893208286 hasAuthorship W2893208286A5027814734 @default.
• W2893208286 hasAuthorship W2893208286A5061969917 @default.
• W2893208286 hasAuthorship W2893208286A5075246930 @default.
• W2893208286 hasAuthorship W2893208286A5083649051 @default.
• W2893208286 hasBestOaLocation W28932082861 @default.
• W2893208286 hasConcept C100691959 @default.
• W2893208286 hasConcept C118552586 @default.
• W2893208286 hasConcept C126322002 @default.
• W2893208286 hasConcept C181199279 @default.
• W2893208286 hasConcept C185592680 @default.
• W2893208286 hasConcept C2775858608 @default.
• W2893208286 hasConcept C2776151105 @default.

• next