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- W2893208631 abstract "Abstract There are two types of interleukin-4 receptor (IL-4R). Type I IL-4R, a heterodimer of IL-4Rα and IL-2RγC, is expressed on cells of hematopoietic origin such as T cells and B cells. In contrast, type II IL-4R, a heterodimer of IL4Rα and IL-13Ra1 is commonly up-regulated in many types of cancer cells including breast cancer and head and neck cancer. Interaction of IL-4 and IL-4R up-regulates anti-apoptotic proteins such as Bcl-xL in tumor cells. In this study, we examined the co-relationship between IL-4R expression and prognosis of patients. In breast cancer patients, high expression levels of IL-13Ra1 subunit of IL-4R was correlated with low overall survival (OS) and disease-free survival (DFS) compared to negative or low expression of IL-13Ra1. However, in oral squamous cell carcinoma patients, high IL-13Ra1 expression was correlated with increased DFS and cancer-specific survival, while high expression of 13Ra1 was correlated with a lower DFS. Next, we tested the feasibility of IL-4R as a therapeutic target IL-4RPep-1 (IL-4 receptor targeting peptide-1), CRKRLDRNC, bound to H226 lung tumor cells that over-express IL4R, while little binding was observed in H460 lung tumor cells that express IL-4R at low levels. When injected intravenously into nude mice bearing a subcutaneous H226 tumor, Cy7.5 near-infrared fluorescence dye-conjugated IL-4RPep-1 selectively homed to tumor. IL-4RPep-1-labeled liposomes containing doxorubicin showed more efficient anti-tumor growth activity than untargeted liposomes. These findings suggest that IL-4R is a promising cancer-related prognosticable biomarker and also therapeutic target for the treatment of cancer." @default.
- W2893208631 created "2018-10-05" @default.
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- W2893208631 date "2018-09-01" @default.
- W2893208631 modified "2023-09-24" @default.
- W2893208631 title "Interleukin-4 receptor as a cancer-related prognosis biomarker and therapeutic target" @default.
- W2893208631 doi "https://doi.org/10.1016/j.mgene.2018.05.039" @default.
- W2893208631 hasPublicationYear "2018" @default.
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