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- W2893212866 abstract "Abstract At earlier stages of clinical development, a static type of trial design to cover phases I–III may seem to be suboptimal. New findings from the running trial, from another trial involving the same compound, or even from unrelated trials testing novel biomarkers may render the original trial design either outdated or insufficient even while the trial is still ongoing. As a common example, one could envision the impact of dose-finding studies on running clinical trials in which the dose estimate from previous experiences, including animal results, may have been used in a prospective larger trial but was found to be insufficient in those newer trials or even in the earlier subjects of the same trial. Thus the ability to adapt a given trial design during the course of its execution seemed highly desirable, and a clinical trial design that allows for prospectively planned modifications to one or more aspects of the design based on accumulating data from subjects in the trial seems to be most appropriate. This adaptive trial design will be discussed in this chapter." @default.
- W2893212866 created "2018-10-05" @default.
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- W2893212866 date "2015-01-01" @default.
- W2893212866 modified "2023-09-26" @default.
- W2893212866 title "Adaptive Trial Design" @default.
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- W2893212866 doi "https://doi.org/10.1016/b978-0-12-800687-0.00025-6" @default.
- W2893212866 hasPublicationYear "2015" @default.
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