FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893215470> ?p ?o ?g. }

• W2893215470 abstract "Background: Non-surgical brain stimulation techniques have been applied as tertiary treatments in major depression. However, the relative efficacy and acceptability of individual protocols is uncertain. Our aim was to estimate the comparative clinical efficacy and acceptability of non-surgical brain stimulation for the acute treatment of major depressive episodes in adults. Methods: Embase, PubMed/MEDLINE and PsycINFO were searched up until May 8, 2018, supplemented by manual searches of bibliographies of recent reviews and included trials. We included clinical trials with random allocation to electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), accelerated TMS (aTMS), priming TMS (pTMS), deep TMS (dTMS), theta burst stimulation (TBS), synchronised TMS (sTMS), magnetic seizure therapy (MST) or transcranial direct current stimulation (tDCS) protocols or sham. Data were extracted from published reports and outcomes were synthesised using pairwise and network random-effects meta-analysis. Primary outcomes were response (efficacy) and all-cause discontinuation (acceptability). We computed odds ratios (OR) with 95% confidence intervals (CI). Remission and continuous post-treatment depression severity scores were also examined. Results: 113 trials (262 treatment arms) randomising 6,750 patients (mean age = 47.9 years; 59% female) with major depressive disorder or bipolar depression met our inclusion criteria. In terms of efficacy, 10 out of 18 treatment protocols were associated with higher response relative to sham in network meta-analysis: bitemporal ECT (OR=8.91, 95%CI 2.57-30.91), high-dose right-unilateral ECT (OR=7.27, 1.90-27.78), pTMS (OR=6.02, 2.21-16.38), MST (OR=5.55, 1.06-28.99), bilateral rTMS (OR=4.92, 2.93-8.25), bilateral TBS (OR=4.44, 1.47-13.41), low-frequency right rTMS (OR=3.65, 2.13-6.24), intermittent TBS (OR=3.20, 1.45-7.08), high-frequency left rTMS (OR=3.17, 2.29-4.37) and tDCS (OR=2.65, 1.55-4.55). Comparing active treatments, bitemporal ECT and high-dose right-unilateral ECT were associated with increased response. All treatment protocols were at least as acceptable as sham treatment. Conclusion: We found that non-surgical brain stimulation techniques constitute viable alternative or add-on treatments for adult patients with major depressive episodes. Our findings also highlight the need to consider other patient and treatment-related factors in addition to antidepressant efficacy and acceptability when making clinical decisions; and emphasize important research priorities in the field of brain stimulation." @default.
• W2893215470 created "2018-10-05" @default.
• W2893215470 creator A5010134941 @default.
• W2893215470 creator A5011557766 @default.
• W2893215470 creator A5017659667 @default.
• W2893215470 creator A5043763422 @default.
• W2893215470 creator A5046465972 @default.
• W2893215470 creator A5058414502 @default.
• W2893215470 date "2018-09-27" @default.
• W2893215470 modified "2023-09-26" @default.
• W2893215470 title "Comparative efficacy and acceptability of non-surgical brain stimulation for the acute treatment of adult major depressive episodes: A systematic review and network meta-analysis of 113 randomised clinical trials" @default.
• W2893215470 cites W1509852289 @default.
• W2893215470 cites W1617328014 @default.
• W2893215470 cites W1643140812 @default.
• W2893215470 cites W1980475719 @default.
• W2893215470 cites W1999286152 @default.
• W2893215470 cites W2018390248 @default.
• W2893215470 cites W2023484210 @default.
• W2893215470 cites W2027559439 @default.
• W2893215470 cites W2030270520 @default.
• W2893215470 cites W2033769262 @default.
• W2893215470 cites W2037593179 @default.
• W2893215470 cites W2042371311 @default.
• W2893215470 cites W2049990060 @default.
• W2893215470 cites W2058805315 @default.
• W2893215470 cites W2063800690 @default.
• W2893215470 cites W2081500918 @default.
• W2893215470 cites W2085803274 @default.
• W2893215470 cites W2091808438 @default.
• W2893215470 cites W2092787589 @default.
• W2893215470 cites W2098923148 @default.
• W2893215470 cites W2109355532 @default.
• W2893215470 cites W2114613490 @default.
• W2893215470 cites W2125435699 @default.
• W2893215470 cites W2129821518 @default.
• W2893215470 cites W2131823335 @default.
• W2893215470 cites W2132324173 @default.
• W2893215470 cites W2137296158 @default.
• W2893215470 cites W2142472354 @default.
• W2893215470 cites W2143805083 @default.
• W2893215470 cites W2150132727 @default.
• W2893215470 cites W2161200711 @default.
• W2893215470 cites W2168773701 @default.
• W2893215470 cites W2171327262 @default.
• W2893215470 cites W2281554882 @default.
• W2893215470 cites W2290116825 @default.
• W2893215470 cites W2327064177 @default.
• W2893215470 cites W2495235786 @default.
• W2893215470 cites W2555091916 @default.
• W2893215470 cites W2562220447 @default.
• W2893215470 cites W2584490100 @default.
• W2893215470 cites W2655991823 @default.
• W2893215470 cites W2783584682 @default.
• W2893215470 cites W2949370209 @default.
• W2893215470 cites W967575156 @default.
• W2893215470 doi "https://doi.org/10.1101/426866" @default.
• W2893215470 hasPublicationYear "2018" @default.
• W2893215470 type Work @default.
• W2893215470 sameAs 2893215470 @default.
• W2893215470 citedByCount "1" @default.
• W2893215470 countsByYear W28932154702019 @default.
• W2893215470 crossrefType "posted-content" @default.
• W2893215470 hasAuthorship W2893215470A5010134941 @default.
• W2893215470 hasAuthorship W2893215470A5011557766 @default.
• W2893215470 hasAuthorship W2893215470A5017659667 @default.
• W2893215470 hasAuthorship W2893215470A5043763422 @default.
• W2893215470 hasAuthorship W2893215470A5046465972 @default.
• W2893215470 hasAuthorship W2893215470A5058414502 @default.
• W2893215470 hasBestOaLocation W28932154701 @default.
• W2893215470 hasConcept C118552586 @default.
• W2893215470 hasConcept C126322002 @default.
• W2893215470 hasConcept C139719470 @default.
• W2893215470 hasConcept C15744967 @default.
• W2893215470 hasConcept C162324750 @default.
• W2893215470 hasConcept C168563851 @default.
• W2893215470 hasConcept C169900460 @default.
• W2893215470 hasConcept C17744445 @default.
• W2893215470 hasConcept C199539241 @default.
• W2893215470 hasConcept C24998067 @default.
• W2893215470 hasConcept C2776412080 @default.
• W2893215470 hasConcept C2776867660 @default.
• W2893215470 hasConcept C2777330709 @default.
• W2893215470 hasConcept C2777342061 @default.
• W2893215470 hasConcept C2778581513 @default.
• W2893215470 hasConcept C2778715236 @default.
• W2893215470 hasConcept C2779473830 @default.
• W2893215470 hasConcept C2779549880 @default.
• W2893215470 hasConcept C2780051608 @default.
• W2893215470 hasConcept C2985799443 @default.
• W2893215470 hasConcept C5048701 @default.
• W2893215470 hasConcept C535046627 @default.
• W2893215470 hasConcept C71924100 @default.
• W2893215470 hasConcept C95190672 @default.
• W2893215470 hasConceptScore W2893215470C118552586 @default.
• W2893215470 hasConceptScore W2893215470C126322002 @default.
• W2893215470 hasConceptScore W2893215470C139719470 @default.
• W2893215470 hasConceptScore W2893215470C15744967 @default.
• W2893215470 hasConceptScore W2893215470C162324750 @default.
• W2893215470 hasConceptScore W2893215470C168563851 @default.
• W2893215470 hasConceptScore W2893215470C169900460 @default.

• next