FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893219036> ?p ?o ?g. }

• W2893219036 endingPage "48" @default.
• W2893219036 startingPage "43" @default.
• W2893219036 abstract "BACKGROUND: Prostate cancers exhibit intratumor heterogeneity (ITH), like other cancer types. The ITH may affect diverse phenotypes such as treatment response, drug resistance, and clinical outcomes. It is crucial to consider ITH to understand tumorigenesis. METHODS: Genomic and transcriptomic profiles of prostate cancer patients were investigated to determine which markers are correlated with the degree of tumor heterogeneity. In addition, the correlation between the immune activity and clonality of tumors was examined. RESULTS: Tumor heterogeneity across all prostate cancer samples was variable. However, ITH events were dependent on genomic and clinical features. Interestingly, prostate-specific antigen score increased in tumors with multiple subclones, indicating high-grade tumor heterogeneity. On the other hand, CD8-positive T-cell activation decreased in highly heterogeneous tumors. Intriguingly, PTEN deletion was prominently enriched in high heterogeneity groups, with a strong association with heterozygous loss. Expression of major genes including PTEN, CDC42EP5, RNLS, GP2, NETO2, and AMPD3 was closely related to tumor heterogeneity in association with PTEN deletion. CONCLUSIONS: In prostate cancer, ITH, a potential factor affecting tumor progression, is associated with PTEN deletion and cytotoxic T cell inactivation." @default.
• W2893219036 created "2018-10-05" @default.
• W2893219036 creator A5003283147 @default.
• W2893219036 creator A5019270039 @default.
• W2893219036 creator A5060488559 @default.
• W2893219036 creator A5060940016 @default.
• W2893219036 creator A5065807862 @default.
• W2893219036 creator A5066737675 @default.
• W2893219036 creator A5070011199 @default.
• W2893219036 date "2019-01-01" @default.
• W2893219036 modified "2023-10-18" @default.
• W2893219036 title "Biomarkers Associated with Tumor Heterogeneity in Prostate Cancer" @default.
• W2893219036 cites W1480357432 @default.
• W2893219036 cites W1489915607 @default.
• W2893219036 cites W1549619413 @default.
• W2893219036 cites W189198258 @default.
• W2893219036 cites W1905250185 @default.
• W2893219036 cites W1968093710 @default.
• W2893219036 cites W1984086503 @default.
• W2893219036 cites W1985987855 @default.
• W2893219036 cites W1986799557 @default.
• W2893219036 cites W1987439849 @default.
• W2893219036 cites W1988079028 @default.
• W2893219036 cites W2000217512 @default.
• W2893219036 cites W2039543196 @default.
• W2893219036 cites W2043829992 @default.
• W2893219036 cites W2078038998 @default.
• W2893219036 cites W2080870285 @default.
• W2893219036 cites W2100024496 @default.
• W2893219036 cites W2101076675 @default.
• W2893219036 cites W2120484554 @default.
• W2893219036 cites W2161112598 @default.
• W2893219036 cites W2182664595 @default.
• W2893219036 cites W2185207072 @default.
• W2893219036 cites W2237809442 @default.
• W2893219036 cites W2565099855 @default.
• W2893219036 cites W2748037493 @default.
• W2893219036 cites W2760216793 @default.
• W2893219036 cites W2765596214 @default.
• W2893219036 cites W2777907803 @default.
• W2893219036 doi "https://doi.org/10.1016/j.tranon.2018.09.003" @default.
• W2893219036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6161410" @default.
• W2893219036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30265975" @default.
• W2893219036 hasPublicationYear "2019" @default.
• W2893219036 type Work @default.
• W2893219036 sameAs 2893219036 @default.
• W2893219036 citedByCount "18" @default.
• W2893219036 countsByYear W28932190362019 @default.
• W2893219036 countsByYear W28932190362020 @default.
• W2893219036 countsByYear W28932190362021 @default.
• W2893219036 countsByYear W28932190362022 @default.
• W2893219036 countsByYear W28932190362023 @default.
• W2893219036 crossrefType "journal-article" @default.
• W2893219036 hasAuthorship W2893219036A5003283147 @default.
• W2893219036 hasAuthorship W2893219036A5019270039 @default.
• W2893219036 hasAuthorship W2893219036A5060488559 @default.
• W2893219036 hasAuthorship W2893219036A5060940016 @default.
• W2893219036 hasAuthorship W2893219036A5065807862 @default.
• W2893219036 hasAuthorship W2893219036A5066737675 @default.
• W2893219036 hasAuthorship W2893219036A5070011199 @default.
• W2893219036 hasBestOaLocation W28932190361 @default.
• W2893219036 hasConcept C104317684 @default.
• W2893219036 hasConcept C121608353 @default.
• W2893219036 hasConcept C126322002 @default.
• W2893219036 hasConcept C127716648 @default.
• W2893219036 hasConcept C143998085 @default.
• W2893219036 hasConcept C150194340 @default.
• W2893219036 hasConcept C162317418 @default.
• W2893219036 hasConcept C167672396 @default.
• W2893219036 hasConcept C190283241 @default.
• W2893219036 hasConcept C203014093 @default.
• W2893219036 hasConcept C2776235491 @default.
• W2893219036 hasConcept C2777609662 @default.
• W2893219036 hasConcept C2779256057 @default.
• W2893219036 hasConcept C2780192828 @default.
• W2893219036 hasConcept C3018028425 @default.
• W2893219036 hasConcept C502942594 @default.
• W2893219036 hasConcept C54355233 @default.
• W2893219036 hasConcept C555283112 @default.
• W2893219036 hasConcept C64618202 @default.
• W2893219036 hasConcept C71924100 @default.
• W2893219036 hasConcept C86554907 @default.
• W2893219036 hasConcept C86803240 @default.
• W2893219036 hasConcept C8891405 @default.
• W2893219036 hasConceptScore W2893219036C104317684 @default.
• W2893219036 hasConceptScore W2893219036C121608353 @default.
• W2893219036 hasConceptScore W2893219036C126322002 @default.
• W2893219036 hasConceptScore W2893219036C127716648 @default.
• W2893219036 hasConceptScore W2893219036C143998085 @default.
• W2893219036 hasConceptScore W2893219036C150194340 @default.
• W2893219036 hasConceptScore W2893219036C162317418 @default.
• W2893219036 hasConceptScore W2893219036C167672396 @default.
• W2893219036 hasConceptScore W2893219036C190283241 @default.
• W2893219036 hasConceptScore W2893219036C203014093 @default.
• W2893219036 hasConceptScore W2893219036C2776235491 @default.
• W2893219036 hasConceptScore W2893219036C2777609662 @default.
• W2893219036 hasConceptScore W2893219036C2779256057 @default.
• W2893219036 hasConceptScore W2893219036C2780192828 @default.

• next