Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893219416> ?p ?o ?g. }
- W2893219416 endingPage "84" @default.
- W2893219416 startingPage "72" @default.
- W2893219416 abstract "Chlorpyrifos, imidacloprid, and α‐cypermethrin are some of the most widely used insecticides in contemporary agriculture. However, their low‐dose, nontarget genotoxic effects have not been extensively assayed. As one of the most relevant cancer biomarkers, we aimed to assess the aneuploidy due to chromosome missegregation during mitosis. To aim it we treated human lymphocytes in vitro with three concentrations of insecticides equivalents relevant for real scenario exposure assessed by regulatory agencies. We focused on chlorpyrifos as conventional and imidacloprid and α‐cypermethrin as sustainable use insecticides. Cytokinesis‐blocked micronucleus assay was performed coupled with fluorescence in situ hybridization (FISH) with directly labeled pancentromeric probes for chromosomes 9, 18, X and Y. None of the insecticides induced significant secondary DNA damage in terms of micronuclei (MN), nuclear buds (NB), or nucleoplasmic bridges (NPB). However, significant disbalances in chromosomes 9, 18, X and Y, and in insecticide‐treated cells has been observed. According to recent studies, these disbalances in chromosome numbers may be atributted to defect sister chromatid cohesion which contribute to the increase of chromosome missegregation but not to micronuclei incidence. We conclude that tested insecticidal active substances exert chromosome missegregation effects at low concentrations, possibly by mechanism of sister chromatid cohesion. These findings may contribute to future risk assesments and understanding of insecticide mode of action on human genome. Environ. Mol. Mutagen. 60:72–84, 2019. © 2018 Wiley Periodicals, Inc." @default.
- W2893219416 created "2018-10-05" @default.
- W2893219416 creator A5047106870 @default.
- W2893219416 creator A5054379684 @default.
- W2893219416 creator A5063025799 @default.
- W2893219416 date "2018-09-27" @default.
- W2893219416 modified "2023-10-02" @default.
- W2893219416 title "Chromosome Missegregation and Aneuploidy Induction in Human Peripheral Blood Lymphocytes <i>In vitro</i> by Low Concentrations of Chlorpyrifos, Imidacloprid and α-Cypermethrin" @default.
- W2893219416 cites W1558701786 @default.
- W2893219416 cites W1740133591 @default.
- W2893219416 cites W1906506906 @default.
- W2893219416 cites W1965707365 @default.
- W2893219416 cites W1966451117 @default.
- W2893219416 cites W1971788371 @default.
- W2893219416 cites W1976270051 @default.
- W2893219416 cites W1976672042 @default.
- W2893219416 cites W1977517445 @default.
- W2893219416 cites W1982912028 @default.
- W2893219416 cites W1987157461 @default.
- W2893219416 cites W1988057804 @default.
- W2893219416 cites W1992315530 @default.
- W2893219416 cites W1992966555 @default.
- W2893219416 cites W1995115894 @default.
- W2893219416 cites W2005325449 @default.
- W2893219416 cites W2006528560 @default.
- W2893219416 cites W2006581393 @default.
- W2893219416 cites W2008191453 @default.
- W2893219416 cites W2009588551 @default.
- W2893219416 cites W2009677754 @default.
- W2893219416 cites W2009968400 @default.
- W2893219416 cites W2011068001 @default.
- W2893219416 cites W2014068395 @default.
- W2893219416 cites W2014494217 @default.
- W2893219416 cites W2027600073 @default.
- W2893219416 cites W2028666395 @default.
- W2893219416 cites W2035862507 @default.
- W2893219416 cites W2037042071 @default.
- W2893219416 cites W2045629744 @default.
- W2893219416 cites W2055570411 @default.
- W2893219416 cites W2057125241 @default.
- W2893219416 cites W2057853942 @default.
- W2893219416 cites W2058503820 @default.
- W2893219416 cites W2059655435 @default.
- W2893219416 cites W2060667783 @default.
- W2893219416 cites W2062896439 @default.
- W2893219416 cites W2063678321 @default.
- W2893219416 cites W2063961309 @default.
- W2893219416 cites W2064149383 @default.
- W2893219416 cites W2073953225 @default.
- W2893219416 cites W2077918393 @default.
- W2893219416 cites W2084069003 @default.
- W2893219416 cites W2086461420 @default.
- W2893219416 cites W2091422162 @default.
- W2893219416 cites W2094661911 @default.
- W2893219416 cites W2101488656 @default.
- W2893219416 cites W2102502996 @default.
- W2893219416 cites W2104336168 @default.
- W2893219416 cites W2107521183 @default.
- W2893219416 cites W2108586779 @default.
- W2893219416 cites W2121392014 @default.
- W2893219416 cites W2127163848 @default.
- W2893219416 cites W2127177111 @default.
- W2893219416 cites W2138713591 @default.
- W2893219416 cites W2142815223 @default.
- W2893219416 cites W2144643123 @default.
- W2893219416 cites W2144800653 @default.
- W2893219416 cites W2156760055 @default.
- W2893219416 cites W2163528675 @default.
- W2893219416 cites W2165959121 @default.
- W2893219416 cites W2166055840 @default.
- W2893219416 cites W2169473323 @default.
- W2893219416 cites W2170445501 @default.
- W2893219416 cites W2187727368 @default.
- W2893219416 cites W2266919750 @default.
- W2893219416 cites W2279607581 @default.
- W2893219416 cites W2305657638 @default.
- W2893219416 cites W2313465146 @default.
- W2893219416 cites W2346074508 @default.
- W2893219416 cites W2418936238 @default.
- W2893219416 cites W2471514741 @default.
- W2893219416 cites W2477107144 @default.
- W2893219416 cites W2491167774 @default.
- W2893219416 cites W2508492321 @default.
- W2893219416 cites W2512304160 @default.
- W2893219416 cites W2513420109 @default.
- W2893219416 cites W2521047878 @default.
- W2893219416 cites W2527963232 @default.
- W2893219416 cites W2553084112 @default.
- W2893219416 cites W2582256818 @default.
- W2893219416 cites W2622194748 @default.
- W2893219416 cites W2623695695 @default.
- W2893219416 cites W2647191113 @default.
- W2893219416 cites W2727055446 @default.
- W2893219416 cites W2742621297 @default.
- W2893219416 cites W2746999023 @default.
- W2893219416 cites W2762604858 @default.
- W2893219416 cites W3150795951 @default.
- W2893219416 cites W4230974614 @default.