Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893221083> ?p ?o ?g. }
- W2893221083 abstract "Summary Synthetic peptidomimetics of antimicrobial peptides are promising as antimicrobial drug candidates because they promote membrane disruption and exhibit greater structural and proteolytic stability. We previously reported selective antifungal 14-helical β-peptides, but the mechanism of antifungal toxicity of β-peptides remains unknown. To provide insight into the mechanism, we studied antifungal β-peptide binding to artificial membranes and living Candida albicans cells. We investigated the ability of β-peptides to interact with and permeate small unilamellar vesicle models of fungal and bacterial membranes. The partition coefficient supported a pore-mediated mechanism characterized by the existence of a critical β-peptide concentration separating low and high partition coefficient regimes. Live cell intracellular tracking of β-peptides showed that β-peptides translocated into the cytoplasm, and then disrupted the nucleus and vacuole sequentially, leading to cell death. This understanding of the mechanisms of antifungal activity will facilitate design and development of peptidomimetic AMPs, including 14-helical β-peptides, for antifungal applications. Graphical Abstract" @default.
- W2893221083 created "2018-10-05" @default.
- W2893221083 creator A5021033521 @default.
- W2893221083 creator A5062284472 @default.
- W2893221083 creator A5072436102 @default.
- W2893221083 creator A5074503965 @default.
- W2893221083 creator A5080790903 @default.
- W2893221083 date "2018-09-29" @default.
- W2893221083 modified "2023-09-29" @default.
- W2893221083 title "14-helical β-peptides Elicit Toxicity against<i>C. albicans</i>by Forming Pores in the Cell Membrane and Subsequently Disrupting Intracellular Organelles" @default.
- W2893221083 cites W1501359805 @default.
- W2893221083 cites W1503300581 @default.
- W2893221083 cites W1590554107 @default.
- W2893221083 cites W1602877696 @default.
- W2893221083 cites W1923665285 @default.
- W2893221083 cites W1940255949 @default.
- W2893221083 cites W1965826522 @default.
- W2893221083 cites W1976258107 @default.
- W2893221083 cites W1976301815 @default.
- W2893221083 cites W1980441078 @default.
- W2893221083 cites W1982004996 @default.
- W2893221083 cites W1984027552 @default.
- W2893221083 cites W1984065278 @default.
- W2893221083 cites W1984607450 @default.
- W2893221083 cites W1985163819 @default.
- W2893221083 cites W1985218385 @default.
- W2893221083 cites W1986447658 @default.
- W2893221083 cites W1989998611 @default.
- W2893221083 cites W1990437549 @default.
- W2893221083 cites W1995412010 @default.
- W2893221083 cites W1998601156 @default.
- W2893221083 cites W2007744639 @default.
- W2893221083 cites W2020969008 @default.
- W2893221083 cites W2024313783 @default.
- W2893221083 cites W2024345691 @default.
- W2893221083 cites W2028122134 @default.
- W2893221083 cites W2028530561 @default.
- W2893221083 cites W2037780945 @default.
- W2893221083 cites W2041584824 @default.
- W2893221083 cites W2045755637 @default.
- W2893221083 cites W2049863531 @default.
- W2893221083 cites W2050535413 @default.
- W2893221083 cites W2053785937 @default.
- W2893221083 cites W2054602599 @default.
- W2893221083 cites W2055555006 @default.
- W2893221083 cites W2056469752 @default.
- W2893221083 cites W2056976674 @default.
- W2893221083 cites W2057198053 @default.
- W2893221083 cites W2057243887 @default.
- W2893221083 cites W2066343236 @default.
- W2893221083 cites W2066817543 @default.
- W2893221083 cites W2073556554 @default.
- W2893221083 cites W2075322040 @default.
- W2893221083 cites W2078424893 @default.
- W2893221083 cites W2079079387 @default.
- W2893221083 cites W2079116535 @default.
- W2893221083 cites W2081277508 @default.
- W2893221083 cites W2085864393 @default.
- W2893221083 cites W2085915211 @default.
- W2893221083 cites W2086264237 @default.
- W2893221083 cites W2086478759 @default.
- W2893221083 cites W2087043215 @default.
- W2893221083 cites W2088667734 @default.
- W2893221083 cites W2091115495 @default.
- W2893221083 cites W2094817022 @default.
- W2893221083 cites W2096559689 @default.
- W2893221083 cites W2097098774 @default.
- W2893221083 cites W2100355668 @default.
- W2893221083 cites W2103461051 @default.
- W2893221083 cites W2115130191 @default.
- W2893221083 cites W2128397296 @default.
- W2893221083 cites W2131909172 @default.
- W2893221083 cites W2134912543 @default.
- W2893221083 cites W2136908127 @default.
- W2893221083 cites W2141896003 @default.
- W2893221083 cites W2143888373 @default.
- W2893221083 cites W2158482458 @default.
- W2893221083 cites W2160780417 @default.
- W2893221083 cites W2164577505 @default.
- W2893221083 cites W2169844371 @default.
- W2893221083 cites W2254198722 @default.
- W2893221083 cites W2257180174 @default.
- W2893221083 cites W2323677389 @default.
- W2893221083 cites W2950422986 @default.
- W2893221083 cites W4252505159 @default.
- W2893221083 doi "https://doi.org/10.1101/430850" @default.
- W2893221083 hasPublicationYear "2018" @default.
- W2893221083 type Work @default.
- W2893221083 sameAs 2893221083 @default.
- W2893221083 citedByCount "1" @default.
- W2893221083 countsByYear W28932210832019 @default.
- W2893221083 crossrefType "posted-content" @default.
- W2893221083 hasAuthorship W2893221083A5021033521 @default.
- W2893221083 hasAuthorship W2893221083A5062284472 @default.
- W2893221083 hasAuthorship W2893221083A5072436102 @default.
- W2893221083 hasAuthorship W2893221083A5074503965 @default.
- W2893221083 hasAuthorship W2893221083A5080790903 @default.
- W2893221083 hasBestOaLocation W28932210831 @default.
- W2893221083 hasConcept C102568950 @default.
- W2893221083 hasConcept C124790011 @default.