Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893223637> ?p ?o ?g. }
- W2893223637 abstract "Phenotypic heterogeneity has been observed in most malignancies, which represents a considerable challenge for tumor therapy. In recent decades, the biological function and clinical significance of the human leukocyte antigen (HLA)-G have been intensively explored. It is now widely accepted that HLA-G is a critical marker of immunotolerance in cancer cell immune evasion and is strongly associated with disease progress and prognosis for cancer patients. Moreover, it has recently been emphasized that the signaling pathway linking HLA-G and immunoglobulin-like transcripts (ILTs) is considered an immune checkpoint. In addition, HLA-G itself can generate at least seven distinct isoforms, and intertumor and intratumor heterogeneity of HLA-G expression is common across different tumor types. Furthermore, HLA-G heterogeneity in cancers has been related to disease stage and outcomes, metastatic status and response to different therapies. This review focuses on the heterogeneity of HLA-G expression in malignant lesions, and clinical implications of this heterogeneity that might be relevant to personalized treatments are also discussed." @default.
- W2893223637 created "2018-10-05" @default.
- W2893223637 creator A5000626725 @default.
- W2893223637 creator A5062857757 @default.
- W2893223637 date "2018-09-27" @default.
- W2893223637 modified "2023-10-14" @default.
- W2893223637 title "Heterogeneity of HLA-G Expression in Cancers: Facing the Challenges" @default.
- W2893223637 cites W1568276869 @default.
- W2893223637 cites W1587234204 @default.
- W2893223637 cites W160271021 @default.
- W2893223637 cites W1757059946 @default.
- W2893223637 cites W1794357844 @default.
- W2893223637 cites W1882502102 @default.
- W2893223637 cites W1896223231 @default.
- W2893223637 cites W1966273058 @default.
- W2893223637 cites W1967263426 @default.
- W2893223637 cites W1968100204 @default.
- W2893223637 cites W1968550069 @default.
- W2893223637 cites W1973193045 @default.
- W2893223637 cites W1975976314 @default.
- W2893223637 cites W1976696463 @default.
- W2893223637 cites W1977176164 @default.
- W2893223637 cites W1978187098 @default.
- W2893223637 cites W1978459180 @default.
- W2893223637 cites W1981158549 @default.
- W2893223637 cites W1981566776 @default.
- W2893223637 cites W1986672594 @default.
- W2893223637 cites W1987413395 @default.
- W2893223637 cites W1989603674 @default.
- W2893223637 cites W1990410073 @default.
- W2893223637 cites W1990412862 @default.
- W2893223637 cites W1991705983 @default.
- W2893223637 cites W1991849405 @default.
- W2893223637 cites W1992101980 @default.
- W2893223637 cites W1997994653 @default.
- W2893223637 cites W2001157494 @default.
- W2893223637 cites W2002220805 @default.
- W2893223637 cites W2002914932 @default.
- W2893223637 cites W2003939651 @default.
- W2893223637 cites W2005917926 @default.
- W2893223637 cites W2007347895 @default.
- W2893223637 cites W2008002517 @default.
- W2893223637 cites W2009328663 @default.
- W2893223637 cites W2011674123 @default.
- W2893223637 cites W2012671068 @default.
- W2893223637 cites W2015650992 @default.
- W2893223637 cites W2017824838 @default.
- W2893223637 cites W2020090091 @default.
- W2893223637 cites W2021582501 @default.
- W2893223637 cites W2021902701 @default.
- W2893223637 cites W2023495487 @default.
- W2893223637 cites W2025592105 @default.
- W2893223637 cites W2026430741 @default.
- W2893223637 cites W2028695120 @default.
- W2893223637 cites W2029175700 @default.
- W2893223637 cites W2032233271 @default.
- W2893223637 cites W2035155248 @default.
- W2893223637 cites W2036792690 @default.
- W2893223637 cites W2038072276 @default.
- W2893223637 cites W2039339794 @default.
- W2893223637 cites W2042724189 @default.
- W2893223637 cites W2043731481 @default.
- W2893223637 cites W2044504875 @default.
- W2893223637 cites W2045585289 @default.
- W2893223637 cites W2046313829 @default.
- W2893223637 cites W2046495164 @default.
- W2893223637 cites W2047418972 @default.
- W2893223637 cites W2048332030 @default.
- W2893223637 cites W2049656655 @default.
- W2893223637 cites W2050346256 @default.
- W2893223637 cites W2055760702 @default.
- W2893223637 cites W2056168413 @default.
- W2893223637 cites W2057024445 @default.
- W2893223637 cites W2059841890 @default.
- W2893223637 cites W2062163694 @default.
- W2893223637 cites W2062894324 @default.
- W2893223637 cites W2064086926 @default.
- W2893223637 cites W2064140853 @default.
- W2893223637 cites W2067696007 @default.
- W2893223637 cites W2068244891 @default.
- W2893223637 cites W2071704959 @default.
- W2893223637 cites W2072617228 @default.
- W2893223637 cites W2074835513 @default.
- W2893223637 cites W2079136653 @default.
- W2893223637 cites W2080512953 @default.
- W2893223637 cites W2081968750 @default.
- W2893223637 cites W2088513266 @default.
- W2893223637 cites W2093879671 @default.
- W2893223637 cites W2094861927 @default.
- W2893223637 cites W2095828046 @default.
- W2893223637 cites W2108463809 @default.
- W2893223637 cites W2112416720 @default.
- W2893223637 cites W2115672176 @default.
- W2893223637 cites W2116277860 @default.
- W2893223637 cites W2121187135 @default.
- W2893223637 cites W2123659889 @default.
- W2893223637 cites W2124683381 @default.
- W2893223637 cites W2125401516 @default.
- W2893223637 cites W2126665111 @default.
- W2893223637 cites W2129129053 @default.