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- W2893224909 abstract "Excitatory synaptic input reaches the soma of a cortical excitatory pyramidal neuron via anatomically segregated apical and basal dendrites. In vivo, dendritic inputs are integrated during depolarized network activity, but how network activity affects apical and basal inputs is not understood. Using subcellular two-photon stimulation of Channelrhodopsin2-expressing layer 2/3 pyramidal neurons in somatosensory cortex, nucleus-specific thalamic optogenetic stimulation, and paired recordings, we show that slow, depolarized network activity amplifies small-amplitude synaptic inputs targeted to basal dendrites but reduces the amplitude of all inputs from apical dendrites and the cell soma. Intracellular pharmacology and mathematical modeling suggests that the amplification of weak basal inputs is mediated by postsynaptic voltage-gated channels. Thus, network activity dynamically reconfigures the relative somatic contribution of apical and basal inputs and could act to enhance the detectability of weak synaptic inputs." @default.
- W2893224909 created "2018-10-05" @default.
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- W2893224909 date "2018-09-01" @default.
- W2893224909 modified "2023-10-15" @default.
- W2893224909 title "Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo" @default.
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- W2893224909 doi "https://doi.org/10.1016/j.celrep.2018.08.088" @default.
- W2893224909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6172694" @default.
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