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- W2893228480 abstract "miRNAs have been shown to regulate a variety of biological process. It has been shown that miR-181a regulates porcine adipogenesis by targeting Tumor Necrosis Factor-α (TNF-α), but the overall functions of miR-181a in porcine preadipocyte differentiation remain unclear. This study aimed to explore the functions of miR-181a in porcine preadipocyte differentiation via the TGFβ/Smad pathway. The TargetScan program was used to predict miRNAs targeting TGFBR1, and miR-181a was selected as a candidate. To investigate the functions of miR-181a, miRNA mimics and inhibitors were used to overexpress or knockdown miR-181a, respectively. RT-qPCR and Western blotting were used to measure the expression of aP2, PPARγ, C/EBPα and TGFBR1 in porcine preadipocytes. Lipid accumulation and adipocyte apoptosis were detected using Oil Red O staining and flow cytometry, respectively. Taken together, our results indicated that miR-181a promoted porcine preadipocyte differentiation by directly targeting TGFBR1." @default.
- W2893228480 created "2018-10-05" @default.
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- W2893228480 date "2019-01-01" @default.
- W2893228480 modified "2023-10-16" @default.
- W2893228480 title "miR-181a regulate porcine preadipocyte differentiation by targeting TGFBR1" @default.
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- W2893228480 doi "https://doi.org/10.1016/j.gene.2018.09.046" @default.
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