Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893229904> ?p ?o ?g. }
- W2893229904 endingPage "351" @default.
- W2893229904 startingPage "339" @default.
- W2893229904 abstract "Abstract TLRs are expressed on the plasma and endosomal membranes of innate immune cells acting as sensors of foreign and inherent danger signals that threaten the host. Upon activation, TLRs facilitate the assembly of large intracellular oligomeric signaling complexes, termed Myddosomes, which initiate key signal transduction pathways to elicit critical inflammatory immune responses. The formation of the Myddosome is integral for TLR signaling; however, the molecular mechanisms controlling its formation, disassembly, and the subsequent proximal signaling events remain to be clearly defined. In this review, we present a brief overview of TLR signal transduction pathways, summarize the current understanding of the Myddosome and the proteins that comprise its structure, including MyD88 and members of the IL-1 receptor-associated kinase (IRAK) family. Finally, we will discuss recent advances and open questions regarding early TLR signaling in the context of the Myddosome complex. Review on our understanding of early TLR signaling with a focus on the Myddosome complex." @default.
- W2893229904 created "2018-10-05" @default.
- W2893229904 creator A5065055789 @default.
- W2893229904 creator A5073962416 @default.
- W2893229904 date "2018-09-26" @default.
- W2893229904 modified "2023-10-11" @default.
- W2893229904 title "Understanding early TLR signaling through the Myddosome" @default.
- W2893229904 cites W1501181174 @default.
- W2893229904 cites W1549853453 @default.
- W2893229904 cites W1612465238 @default.
- W2893229904 cites W1755844030 @default.
- W2893229904 cites W1765013689 @default.
- W2893229904 cites W1963751749 @default.
- W2893229904 cites W1964985092 @default.
- W2893229904 cites W1965658052 @default.
- W2893229904 cites W1965971815 @default.
- W2893229904 cites W1966680360 @default.
- W2893229904 cites W1966772446 @default.
- W2893229904 cites W1967269498 @default.
- W2893229904 cites W1968336033 @default.
- W2893229904 cites W1969380065 @default.
- W2893229904 cites W1969430178 @default.
- W2893229904 cites W1969501356 @default.
- W2893229904 cites W1969941746 @default.
- W2893229904 cites W1973748965 @default.
- W2893229904 cites W1975455569 @default.
- W2893229904 cites W1981368434 @default.
- W2893229904 cites W1983072212 @default.
- W2893229904 cites W1989656760 @default.
- W2893229904 cites W1992999021 @default.
- W2893229904 cites W1993211211 @default.
- W2893229904 cites W1993783912 @default.
- W2893229904 cites W1996120614 @default.
- W2893229904 cites W1997767982 @default.
- W2893229904 cites W1998585620 @default.
- W2893229904 cites W1999286245 @default.
- W2893229904 cites W2000530029 @default.
- W2893229904 cites W2001256354 @default.
- W2893229904 cites W2009005217 @default.
- W2893229904 cites W2009392385 @default.
- W2893229904 cites W2015263036 @default.
- W2893229904 cites W2017883909 @default.
- W2893229904 cites W2025124540 @default.
- W2893229904 cites W2025761802 @default.
- W2893229904 cites W2030618676 @default.
- W2893229904 cites W2032972084 @default.
- W2893229904 cites W2033735518 @default.
- W2893229904 cites W2034399368 @default.
- W2893229904 cites W2034615108 @default.
- W2893229904 cites W2034763496 @default.
- W2893229904 cites W2036475326 @default.
- W2893229904 cites W2038554653 @default.
- W2893229904 cites W2043823247 @default.
- W2893229904 cites W2043981380 @default.
- W2893229904 cites W2046743509 @default.
- W2893229904 cites W2048412291 @default.
- W2893229904 cites W2049874360 @default.
- W2893229904 cites W2054979063 @default.
- W2893229904 cites W2065262396 @default.
- W2893229904 cites W2066205838 @default.
- W2893229904 cites W2068031486 @default.
- W2893229904 cites W2070597700 @default.
- W2893229904 cites W2077648685 @default.
- W2893229904 cites W2078565488 @default.
- W2893229904 cites W2084832493 @default.
- W2893229904 cites W2087098495 @default.
- W2893229904 cites W2088768592 @default.
- W2893229904 cites W2089938437 @default.
- W2893229904 cites W2092703416 @default.
- W2893229904 cites W2092713838 @default.
- W2893229904 cites W2094045593 @default.
- W2893229904 cites W2094148186 @default.
- W2893229904 cites W2096118019 @default.
- W2893229904 cites W2104960311 @default.
- W2893229904 cites W2107315506 @default.
- W2893229904 cites W2110827592 @default.
- W2893229904 cites W2110853277 @default.
- W2893229904 cites W2111428445 @default.
- W2893229904 cites W2115101250 @default.
- W2893229904 cites W2115185894 @default.
- W2893229904 cites W2116382435 @default.
- W2893229904 cites W2118224132 @default.
- W2893229904 cites W2121830340 @default.
- W2893229904 cites W2126829776 @default.
- W2893229904 cites W2129319296 @default.
- W2893229904 cites W2130421043 @default.
- W2893229904 cites W2134847649 @default.
- W2893229904 cites W2137590150 @default.
- W2893229904 cites W2140380015 @default.
- W2893229904 cites W2141040025 @default.
- W2893229904 cites W2141150979 @default.
- W2893229904 cites W2145110660 @default.
- W2893229904 cites W2147038697 @default.
- W2893229904 cites W2151993654 @default.
- W2893229904 cites W2157086104 @default.
- W2893229904 cites W2163558504 @default.
- W2893229904 cites W2165448884 @default.
- W2893229904 cites W2165591553 @default.