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- W2893232755 abstract "Over the past few years, new-generation cell-based assays have demonstrated a robust association of autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, myelitis and brainstem encephalitis, as well as with acute disseminated encephalomyelitis (ADEM)-like presentations. Most experts now consider MOG-IgG-associated encephalomyelitis (MOG-EM) a disease entity in its own right, immunopathogenetically distinct from both classic multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorders (NMOSD). Owing to a substantial overlap in clinicoradiological presentation, MOG-EM was often unwittingly misdiagnosed as MS in the past. Accordingly, increasing numbers of patients with suspected or established MS are currently being tested for MOG-IgG. However, screening of large unselected cohorts for rare biomarkers can significantly reduce the positive predictive value of a test. To lessen the hazard of overdiagnosing MOG-EM, which may lead to inappropriate treatment, more selective criteria for MOG-IgG testing are urgently needed. In this paper, we propose indications for MOG-IgG testing based on expert consensus. In addition, we give a list of conditions atypical for MOG-EM (red flags) that should prompt physicians to challenge a positive MOG-IgG test result. Finally, we provide recommendations regarding assay methodology, specimen sampling and data interpretation, and propose for the first time diagnostic criteria for MOG-EM." @default.
- W2893232755 created "2018-10-05" @default.
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- W2893232755 date "2018-09-27" @default.
- W2893232755 modified "2023-10-14" @default.
- W2893232755 title "MOG-Enzephalomyelitis: Internationale Empfehlungen zu Diagnose und Antikörpertestung" @default.
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- W2893232755 doi "https://doi.org/10.1007/s00115-018-0607-0" @default.
- W2893232755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30264269" @default.
- W2893232755 hasPublicationYear "2018" @default.