FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893239474> ?p ?o ?g. }

• W2893239474 endingPage "6741" @default.
• W2893239474 startingPage "6735" @default.
• W2893239474 abstract "BACKGROUND:This study aimed to investigate the effect of deferoxamine (DFO) on leukemia in vitro, and to explore the underlying molecular mechanism. MATERIAL AND METHODS:K562 leukemia cells were treated with various concentrations of DFO (10, 50, and 100 µmol/l) with or without 10 µmol/l ferric chloride for 12 h. Then, total cellular iron was detected. CCK-8 kit and flow cytometry were used for cell viability and apoptosis detection. In addition, expression of apoptosis-related genes was determined by Western blotting and qRT-PCR, respectively. RESULTS:The results suggested that DFO significantly inhibited K562 cell viability and induced cell apoptosis in a dose-dependent manner. We also found that the protein and mRNA levels of Bax, p53, and Fas dose-dependently increased in DFO-treated K562 cells, while the level of Bcl-2 markedly decreased in a dose-dependent manner. Moreover, the findings showed that ferric chloride eliminated these effects on K562 cells caused by DFO treatment. CONCLUSIONS:Our results indicate that DFO plays a protective role in leukemia via inhibiting leukemia cell viability and inducing cell apoptosis by the regulation of apoptosis-related genes expression." @default.
• W2893239474 created "2018-10-05" @default.
• W2893239474 creator A5000341131 @default.
• W2893239474 creator A5004923337 @default.
• W2893239474 creator A5008196874 @default.
• W2893239474 creator A5015904488 @default.
• W2893239474 creator A5067536216 @default.
• W2893239474 date "2018-09-24" @default.
• W2893239474 modified "2023-09-26" @default.
• W2893239474 title "Effects of Deferoxamine on Leukemia In Vitro and Its Related Mechanism" @default.
• W2893239474 cites W1564930378 @default.
• W2893239474 cites W1973995624 @default.
• W2893239474 cites W1977512210 @default.
• W2893239474 cites W1981610976 @default.
• W2893239474 cites W2009502782 @default.
• W2893239474 cites W2053458496 @default.
• W2893239474 cites W2062107099 @default.
• W2893239474 cites W2069457578 @default.
• W2893239474 cites W2076994280 @default.
• W2893239474 cites W2079639660 @default.
• W2893239474 cites W2083632279 @default.
• W2893239474 cites W2114015514 @default.
• W2893239474 cites W2134355296 @default.
• W2893239474 cites W2144576921 @default.
• W2893239474 cites W2150007817 @default.
• W2893239474 cites W2518233756 @default.
• W2893239474 cites W2518298055 @default.
• W2893239474 cites W2530090310 @default.
• W2893239474 cites W2545478696 @default.
• W2893239474 cites W2556367569 @default.
• W2893239474 cites W2583934405 @default.
• W2893239474 cites W2598511595 @default.
• W2893239474 cites W2763700508 @default.
• W2893239474 cites W2789427144 @default.
• W2893239474 cites W2792078738 @default.
• W2893239474 cites W2793740807 @default.
• W2893239474 cites W3021502711 @default.
• W2893239474 doi "https://doi.org/10.12659/msm.910325" @default.
• W2893239474 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6180944" @default.
• W2893239474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30246777" @default.
• W2893239474 hasPublicationYear "2018" @default.
• W2893239474 type Work @default.
• W2893239474 sameAs 2893239474 @default.
• W2893239474 citedByCount "15" @default.
• W2893239474 countsByYear W28932394742019 @default.
• W2893239474 countsByYear W28932394742020 @default.
• W2893239474 countsByYear W28932394742021 @default.
• W2893239474 countsByYear W28932394742022 @default.
• W2893239474 crossrefType "journal-article" @default.
• W2893239474 hasAuthorship W2893239474A5000341131 @default.
• W2893239474 hasAuthorship W2893239474A5004923337 @default.
• W2893239474 hasAuthorship W2893239474A5008196874 @default.
• W2893239474 hasAuthorship W2893239474A5015904488 @default.
• W2893239474 hasAuthorship W2893239474A5067536216 @default.
• W2893239474 hasBestOaLocation W28932394742 @default.
• W2893239474 hasConcept C104317684 @default.
• W2893239474 hasConcept C1491633281 @default.
• W2893239474 hasConcept C153911025 @default.
• W2893239474 hasConcept C171122931 @default.
• W2893239474 hasConcept C185592680 @default.
• W2893239474 hasConcept C190283241 @default.
• W2893239474 hasConcept C202751555 @default.
• W2893239474 hasConcept C203014093 @default.
• W2893239474 hasConcept C2776672577 @default.
• W2893239474 hasConcept C2778461978 @default.
• W2893239474 hasConcept C2778729363 @default.
• W2893239474 hasConcept C502942594 @default.
• W2893239474 hasConcept C53227056 @default.
• W2893239474 hasConcept C54355233 @default.
• W2893239474 hasConcept C553184892 @default.
• W2893239474 hasConcept C55493867 @default.
• W2893239474 hasConcept C81885089 @default.
• W2893239474 hasConcept C85265743 @default.
• W2893239474 hasConcept C86803240 @default.
• W2893239474 hasConcept C98274493 @default.
• W2893239474 hasConceptScore W2893239474C104317684 @default.
• W2893239474 hasConceptScore W2893239474C1491633281 @default.
• W2893239474 hasConceptScore W2893239474C153911025 @default.
• W2893239474 hasConceptScore W2893239474C171122931 @default.
• W2893239474 hasConceptScore W2893239474C185592680 @default.
• W2893239474 hasConceptScore W2893239474C190283241 @default.
• W2893239474 hasConceptScore W2893239474C202751555 @default.
• W2893239474 hasConceptScore W2893239474C203014093 @default.
• W2893239474 hasConceptScore W2893239474C2776672577 @default.
• W2893239474 hasConceptScore W2893239474C2778461978 @default.
• W2893239474 hasConceptScore W2893239474C2778729363 @default.
• W2893239474 hasConceptScore W2893239474C502942594 @default.
• W2893239474 hasConceptScore W2893239474C53227056 @default.
• W2893239474 hasConceptScore W2893239474C54355233 @default.
• W2893239474 hasConceptScore W2893239474C553184892 @default.
• W2893239474 hasConceptScore W2893239474C55493867 @default.
• W2893239474 hasConceptScore W2893239474C81885089 @default.
• W2893239474 hasConceptScore W2893239474C85265743 @default.
• W2893239474 hasConceptScore W2893239474C86803240 @default.
• W2893239474 hasConceptScore W2893239474C98274493 @default.
• W2893239474 hasLocation W28932394741 @default.
• W2893239474 hasLocation W28932394742 @default.
• W2893239474 hasLocation W28932394743 @default.

• next