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- W2893240177 abstract "A 56-year-old woman complained of an exophytic nodular lesion on the floor of the mouth, causing paresthesia of the tongue. An incisional biopsy was performed and revealed a neoplasia composed of nests of clear-cytoplasm cells permeated by bundles of hyalinized stroma. The diagnosis of hyalinizing clear cell carcinoma was established. The patient underwent a complete excision of the lesion, with neck dissection; the histopathological examination revealed an undifferentiated carcinoma with a nodular architecture composed of solid clusters of cells with a broad and clear cytoplasm in an abundant fibrous stroma, presence of necrosis, with perineural and angiovascular invasion. The immunohistochemical test was positive for AE1/AE3, CK5, and p63, and negative for CD20, CD3, CDX-2, p16, S-100, estrogen receptor, and TTF-1. For a better classification of this undifferentiated carcinoma, amplification of the immunohistochemical panel is required. The patient showed no signs of recurrence over 2 months of follow-up." @default.
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- W2893240177 date "2018-09-01" @default.
- W2893240177 modified "2023-09-27" @default.
- W2893240177 title "Diagnostic Challenge in a Case of Malignant Salivary Gland Neoplasm on the Floor of the Mouth" @default.
- W2893240177 doi "https://doi.org/10.1016/j.oooo.2018.02.536" @default.
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