FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893247092> ?p ?o ?g. }

• W2893247092 endingPage "e0204936" @default.
• W2893247092 startingPage "e0204936" @default.
• W2893247092 abstract "Virulent strains of Pseudomonas aeruginosa are often associated with an acquired cytotoxic protein, exoenzyme U (ExoU) that rapidly destroys the cell membranes of host cells by its phospholipase activity. Strains possessing the exoU gene are predominant in eye infections and are more resistant to antibiotics. Thus, it is essential to understand treatment options for these strains. Here, we have investigated the resistance profiles and genes associated with resistance for fluoroquinolone and beta-lactams. A total of 22 strains of P. aeruginosa from anterior eye infections, microbial keratitis (MK), and the lungs of cystic fibrosis (CF) patients were used. Based on whole genome sequencing, the prevalence of the exoU gene was 61.5% in MK isolates whereas none of the CF isolates possessed this gene. Overall, higher antibiotic resistance was observed in the isolates possessing exoU. Of the exoU strains, all except one were resistant to fluoroquinolones, 100% were resistant to beta-lactams. 75% had mutations in quinolone resistance determining regions (T81I gyrA and/or S87L parC) which correlated with fluoroquinolone resistance. In addition, exoU strains had mutations at K76Q, A110T, and V126E in ampC, Q155I and V356I in ampR and E114A, G283E, and M288R in mexR genes that are associated with higher beta-lactamase and efflux pump activities. In contrast, such mutations were not observed in the strains lacking exoU. The expression of the ampC gene increased by up to nine-fold in all eight exoU strains and the ampR was upregulated in seven exoU strains compared to PAO1. The expression of mexR gene was 1.4 to 3.6 fold lower in 75% of exoU strains. This study highlights the association between virulence traits and antibiotic resistance in pathogenic P. aeruginosa." @default.
• W2893247092 created "2018-10-05" @default.
• W2893247092 creator A5041541800 @default.
• W2893247092 creator A5053126836 @default.
• W2893247092 creator A5054628624 @default.
• W2893247092 creator A5070048995 @default.
• W2893247092 creator A5078503977 @default.
• W2893247092 date "2018-09-28" @default.
• W2893247092 modified "2023-10-12" @default.
• W2893247092 title "Association between possession of ExoU and antibiotic resistance in Pseudomonas aeruginosa" @default.
• W2893247092 cites W1784682786 @default.
• W2893247092 cites W1959513603 @default.
• W2893247092 cites W1971088549 @default.
• W2893247092 cites W1978638662 @default.
• W2893247092 cites W1979973356 @default.
• W2893247092 cites W1987401630 @default.
• W2893247092 cites W1990810367 @default.
• W2893247092 cites W1999605501 @default.
• W2893247092 cites W2009087678 @default.
• W2893247092 cites W2010872522 @default.
• W2893247092 cites W2015211917 @default.
• W2893247092 cites W2034279867 @default.
• W2893247092 cites W2038848856 @default.
• W2893247092 cites W2052280627 @default.
• W2893247092 cites W2058004284 @default.
• W2893247092 cites W2058246783 @default.
• W2893247092 cites W2067906280 @default.
• W2893247092 cites W2077049678 @default.
• W2893247092 cites W2077424820 @default.
• W2893247092 cites W2077668745 @default.
• W2893247092 cites W2079895158 @default.
• W2893247092 cites W2088668105 @default.
• W2893247092 cites W2089404976 @default.
• W2893247092 cites W2096093282 @default.
• W2893247092 cites W2099303284 @default.
• W2893247092 cites W2106359046 @default.
• W2893247092 cites W2106578986 @default.
• W2893247092 cites W2108187249 @default.
• W2893247092 cites W2108234281 @default.
• W2893247092 cites W2114570899 @default.
• W2893247092 cites W2115402841 @default.
• W2893247092 cites W2120902911 @default.
• W2893247092 cites W2125731426 @default.
• W2893247092 cites W2128075445 @default.
• W2893247092 cites W2128179514 @default.
• W2893247092 cites W2129781699 @default.
• W2893247092 cites W2131256712 @default.
• W2893247092 cites W2149353640 @default.
• W2893247092 cites W2150637507 @default.
• W2893247092 cites W2150783076 @default.
• W2893247092 cites W2156473891 @default.
• W2893247092 cites W2158102238 @default.
• W2893247092 cites W2158534342 @default.
• W2893247092 cites W2160000575 @default.
• W2893247092 cites W2160512425 @default.
• W2893247092 cites W2164296090 @default.
• W2893247092 cites W2164987838 @default.
• W2893247092 cites W2170551349 @default.
• W2893247092 cites W2180752973 @default.
• W2893247092 cites W2219714852 @default.
• W2893247092 cites W2271827860 @default.
• W2893247092 cites W2294133064 @default.
• W2893247092 cites W2341432130 @default.
• W2893247092 cites W2433286109 @default.
• W2893247092 cites W2486445110 @default.
• W2893247092 cites W2514390937 @default.
• W2893247092 cites W2528087434 @default.
• W2893247092 cites W2593935854 @default.
• W2893247092 cites W4211155552 @default.
• W2893247092 cites W76027400 @default.
• W2893247092 doi "https://doi.org/10.1371/journal.pone.0204936" @default.
• W2893247092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6161911" @default.
• W2893247092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30265709" @default.
• W2893247092 hasPublicationYear "2018" @default.
• W2893247092 type Work @default.
• W2893247092 sameAs 2893247092 @default.
• W2893247092 citedByCount "35" @default.
• W2893247092 countsByYear W28932470922018 @default.
• W2893247092 countsByYear W28932470922019 @default.
• W2893247092 countsByYear W28932470922020 @default.
• W2893247092 countsByYear W28932470922021 @default.
• W2893247092 countsByYear W28932470922022 @default.
• W2893247092 countsByYear W28932470922023 @default.
• W2893247092 crossrefType "journal-article" @default.
• W2893247092 hasAuthorship W2893247092A5041541800 @default.
• W2893247092 hasAuthorship W2893247092A5053126836 @default.
• W2893247092 hasAuthorship W2893247092A5054628624 @default.
• W2893247092 hasAuthorship W2893247092A5070048995 @default.
• W2893247092 hasAuthorship W2893247092A5078503977 @default.
• W2893247092 hasBestOaLocation W28932470921 @default.
• W2893247092 hasConcept C104317684 @default.
• W2893247092 hasConcept C118687296 @default.
• W2893247092 hasConcept C200082930 @default.
• W2893247092 hasConcept C2776738503 @default.
• W2893247092 hasConcept C2777637488 @default.
• W2893247092 hasConcept C2781427627 @default.
• W2893247092 hasConcept C501593827 @default.
• W2893247092 hasConcept C523546767 @default.

• next