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• W2893247414 endingPage "5014" @default.
• W2893247414 startingPage "5002" @default.
• W2893247414 abstract "On the nucleosome level, histone posttranslational modifications function mainly as the regulatory signals; in addition, some posttranslational modifications can enhance nucleosome stochastic folding, which is restricted in “canonic” nucleosomes. Recently, it has been shown in vitro that symmetric or asymmetric nucleosome ubiquitylation at H2BK34 (and H2BK120, to a lesser extent) can destabilize one of the nucleosomal H2A–H2B dimers and promote nucleosome conversion to a hexasome particle [Krajewski et al. (2018). Nucleic Acids Res., 46, 7631–7642]. Such lability of H2Bub nucleosomes raises a question of whether they could accommodate transient changes in DNA torsional tensions, which are generated by virtually any process that manipulates DNA strands. Using positively or negatively supercoiled DNA minicircles and homogeneously-modified H2Bub histones, we have found that DNA topology could strongly and selectively affect nucleosome stability depending on its ubiquitylation state (here the term “nucleosome stability” means the nucleosome property to maintain its structural integrity and dynamics characteristic to “canonic” nucleosomes). The results point to a role for H2B ubiquitylation in amplifying or mitigating the effects of a DNA torque on the nucleosome stability and dynamics." @default.
• W2893247414 created "2018-10-05" @default.
• W2893247414 creator A5030917475 @default.
• W2893247414 date "2018-12-01" @default.
• W2893247414 modified "2023-10-15" @default.
• W2893247414 title "Effects of DNA Superhelical Stress on the Stability of H2B-Ubiquitylated Nucleosomes" @default.
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• W2893247414 doi "https://doi.org/10.1016/j.jmb.2018.09.014" @default.
• W2893247414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30267746" @default.

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