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- W2893257926 endingPage "2491" @default.
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- W2893257926 abstract "Abstract Drug use leads to addiction in some individuals, but the underlying brain mechanisms that control the transition from casual drug use to an intractable substance use disorder ( SUD ) are not well understood. Gene x environment interactions such as the frequency of drug use and the type of substance used likely to promote maladaptive plastic changes in brain regions that are critical for controlling addiction‐related behavior. Epigenetics encompasses a broad spectrum of mechanisms important for regulating gene transcription that are not dependent on changes in DNA base pair sequences. This review focuses on the proteins and complexes contributing to epigenetic modifications in the nucleus accumbens ( NA c) following drug experience. We discuss in detail the three major mechanisms: histone acetylation and deacetylation, histone methylation, and DNA methylation. We discuss how drug use alters the regulation of the associated proteins regulating these processes and highlight how experimental manipulations of these proteins in the NA c can alter drug‐related behaviors. Finally, we discuss the ways that histone modifications and DNA methylation coordinate actions by recruiting large epigenetic enzyme complexes to aid in transcriptional repression. Targeting these multiprotein epigenetic enzyme complexes – and the individual proteins that comprise them – might lead to effective therapeutics to reverse or treat SUD s in patients." @default.
- W2893257926 created "2018-10-05" @default.
- W2893257926 creator A5020907284 @default.
- W2893257926 creator A5021887669 @default.
- W2893257926 creator A5024497295 @default.
- W2893257926 creator A5055352858 @default.
- W2893257926 creator A5062705699 @default.
- W2893257926 creator A5066830005 @default.
- W2893257926 date "2018-10-10" @default.
- W2893257926 modified "2023-10-16" @default.
- W2893257926 title "It is a complex issue: emerging connections between epigenetic regulators in drug addiction" @default.
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