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- W2893259704 endingPage "1016" @default.
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- W2893259704 abstract "Abstract Recent accelerated approvals of Chimeric Antigen Receptor T‐cell (CAR‐T) therapies targeting refractory haematological malignancies underscore the potential for this novel technology platform to provide new therapeutic options for oncology areas with high unmet medical needs. However, these powerful ‘living drugs’ are markedly different to conventional small molecule and biologic therapies on several levels. The highly complex nature and varied composition of CAR‐T based products still requires considerable investigation to resolve the best approaches to ensure reproducible and cost‐effective manufacture, clinical development, and application. This review will focus on key issues for manufacturing and quality control of these exciting new therapeutic modalities, preceded by a brief description of CAR principals and clinical development considerations. © 2018 The Authors. Journal of Chemical Technology & Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry." @default.
- W2893259704 created "2018-10-05" @default.
- W2893259704 creator A5012995987 @default.
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- W2893259704 creator A5055794524 @default.
- W2893259704 creator A5071552976 @default.
- W2893259704 creator A5081034123 @default.
- W2893259704 date "2018-11-19" @default.
- W2893259704 modified "2023-10-12" @default.
- W2893259704 title "Cell therapy products: focus on issues with manufacturing and quality control of chimeric antigen receptor T‐cell therapies" @default.
- W2893259704 cites W1507547677 @default.
- W2893259704 cites W1555059873 @default.
- W2893259704 cites W1619537825 @default.
- W2893259704 cites W1637867377 @default.
- W2893259704 cites W1910881826 @default.
- W2893259704 cites W1933257534 @default.
- W2893259704 cites W1970949842 @default.
- W2893259704 cites W1977955083 @default.
- W2893259704 cites W1979829306 @default.
- W2893259704 cites W1982795546 @default.
- W2893259704 cites W1986543208 @default.
- W2893259704 cites W1988180497 @default.
- W2893259704 cites W1988658880 @default.
- W2893259704 cites W1994993231 @default.
- W2893259704 cites W2010803340 @default.
- W2893259704 cites W2023375384 @default.
- W2893259704 cites W2035098907 @default.
- W2893259704 cites W2043577668 @default.
- W2893259704 cites W2045995615 @default.
- W2893259704 cites W2047192675 @default.
- W2893259704 cites W2051713886 @default.
- W2893259704 cites W2060902798 @default.
- W2893259704 cites W2064272625 @default.
- W2893259704 cites W2079000181 @default.
- W2893259704 cites W2085060041 @default.
- W2893259704 cites W2085645098 @default.
- W2893259704 cites W2087209798 @default.
- W2893259704 cites W2091038501 @default.
- W2893259704 cites W2093762704 @default.
- W2893259704 cites W2098415958 @default.
- W2893259704 cites W2098686083 @default.
- W2893259704 cites W2099736081 @default.
- W2893259704 cites W2104597364 @default.
- W2893259704 cites W2133298966 @default.
- W2893259704 cites W2145067668 @default.
- W2893259704 cites W2145985838 @default.
- W2893259704 cites W2153520524 @default.
- W2893259704 cites W2156491299 @default.
- W2893259704 cites W2166465167 @default.
- W2893259704 cites W2166948779 @default.
- W2893259704 cites W2182861461 @default.
- W2893259704 cites W2207393676 @default.
- W2893259704 cites W2217081146 @default.
- W2893259704 cites W2228689854 @default.
- W2893259704 cites W2239932467 @default.
- W2893259704 cites W2253938658 @default.
- W2893259704 cites W2302851559 @default.
- W2893259704 cites W2321958889 @default.
- W2893259704 cites W2332838743 @default.
- W2893259704 cites W2333997296 @default.
- W2893259704 cites W2342423058 @default.
- W2893259704 cites W2404657615 @default.
- W2893259704 cites W2437650321 @default.
- W2893259704 cites W2443085751 @default.
- W2893259704 cites W2460088816 @default.
- W2893259704 cites W2462177828 @default.
- W2893259704 cites W2462961870 @default.
- W2893259704 cites W2470125153 @default.
- W2893259704 cites W2475107749 @default.
- W2893259704 cites W2500107307 @default.
- W2893259704 cites W2509364267 @default.
- W2893259704 cites W2519710256 @default.
- W2893259704 cites W2548694234 @default.
- W2893259704 cites W2566677727 @default.
- W2893259704 cites W2567407553 @default.
- W2893259704 cites W2567664749 @default.
- W2893259704 cites W2573216598 @default.
- W2893259704 cites W2583070206 @default.
- W2893259704 cites W2587691649 @default.
- W2893259704 cites W2588448039 @default.
- W2893259704 cites W2588571054 @default.
- W2893259704 cites W2589417329 @default.
- W2893259704 cites W2589755395 @default.
- W2893259704 cites W2592735801 @default.
- W2893259704 cites W2593621980 @default.
- W2893259704 cites W2596442933 @default.
- W2893259704 cites W2599193187 @default.
- W2893259704 cites W2599238585 @default.
- W2893259704 cites W2604982880 @default.
- W2893259704 cites W2607660437 @default.
- W2893259704 cites W2611416869 @default.
- W2893259704 cites W2612308664 @default.
- W2893259704 cites W2612351834 @default.
- W2893259704 cites W2619886251 @default.
- W2893259704 cites W2620841039 @default.
- W2893259704 cites W2625536756 @default.
- W2893259704 cites W2732311975 @default.