FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893267975> ?p ?o ?g. }

• W2893267975 endingPage "150" @default.
• W2893267975 startingPage "143" @default.
• W2893267975 abstract "BackgroundMitral valve anomalies in children are rare but frequently severe, recalcitrant, and not often amenable to primary repair, necessitating mechanical mitral valve replacement (M-MVR). This study examined outcomes of a cohort undergoing a first M-MVR at age younger than 21 years.MethodsWe queried the Pediatric Cardiac Care Consortium, a multi-institutional United States-based cardiac intervention registry, for patients undergoing first M-MVR for 2-ventricle congenital heart disease. Survival and transplant status through 2014 were obtained from Pediatric Cardiac Care Consortium and linkage with the National Death Index and the Organ Procurement and Transplantation Network.ResultsWe identified 441 patients (median age, 4.3 years; interquartile range, 1.3 to 10.1 years) meeting study criteria. The commonest disease necessitating M-MVR was atrioventricular canal (44.3%). Early mortality (death <90 days after M-MVR) was 11.1%; there was increased risk of early death if age at M-MVR was younger than 2 years (odds ratio, 7.8; 95% confidence interval [CI], 1.1 to 56.6) and with concurrent other mechanical valve placement (odds ratio, 8.5; 95% CI, 2.0 to 35.6). In those surviving more than 90 days after M-MVR, transplant-free survival was 76% at 20 years of follow-up (median follow-up, 16.6 years; interquartile range, 11.9 to 21.3 years). Adjusted analysis in those who survived more than 90 days showed elevated risk of death/transplant for boys (hazard ratio, 1.5; 95% CI, 1.0 to 2.3), age at M-MVR younger than 2 years (10-year survival: hazard ratio, 4.3; 95% CI, 1.2 to 15.1), and nonbileaflet prosthesis placement (hazard ratio, 2.4; 95% CI, 1.3 to 4.3).ConclusionsM-MVR is a viable strategy in children with unrepairable mitral valve disease. Age younger than 2 years at the first M-MVR is associated with significant early risk of death and poorer long-term survival. Mitral valve anomalies in children are rare but frequently severe, recalcitrant, and not often amenable to primary repair, necessitating mechanical mitral valve replacement (M-MVR). This study examined outcomes of a cohort undergoing a first M-MVR at age younger than 21 years. We queried the Pediatric Cardiac Care Consortium, a multi-institutional United States-based cardiac intervention registry, for patients undergoing first M-MVR for 2-ventricle congenital heart disease. Survival and transplant status through 2014 were obtained from Pediatric Cardiac Care Consortium and linkage with the National Death Index and the Organ Procurement and Transplantation Network. We identified 441 patients (median age, 4.3 years; interquartile range, 1.3 to 10.1 years) meeting study criteria. The commonest disease necessitating M-MVR was atrioventricular canal (44.3%). Early mortality (death <90 days after M-MVR) was 11.1%; there was increased risk of early death if age at M-MVR was younger than 2 years (odds ratio, 7.8; 95% confidence interval [CI], 1.1 to 56.6) and with concurrent other mechanical valve placement (odds ratio, 8.5; 95% CI, 2.0 to 35.6). In those surviving more than 90 days after M-MVR, transplant-free survival was 76% at 20 years of follow-up (median follow-up, 16.6 years; interquartile range, 11.9 to 21.3 years). Adjusted analysis in those who survived more than 90 days showed elevated risk of death/transplant for boys (hazard ratio, 1.5; 95% CI, 1.0 to 2.3), age at M-MVR younger than 2 years (10-year survival: hazard ratio, 4.3; 95% CI, 1.2 to 15.1), and nonbileaflet prosthesis placement (hazard ratio, 2.4; 95% CI, 1.3 to 4.3). M-MVR is a viable strategy in children with unrepairable mitral valve disease. Age younger than 2 years at the first M-MVR is associated with significant early risk of death and poorer long-term survival." @default.
• W2893267975 created "2018-10-05" @default.
• W2893267975 creator A5010118231 @default.
• W2893267975 creator A5012797487 @default.
• W2893267975 creator A5014402173 @default.
• W2893267975 creator A5018345253 @default.
• W2893267975 creator A5020335308 @default.
• W2893267975 creator A5029393460 @default.
• W2893267975 creator A5031664133 @default.
• W2893267975 creator A5033267892 @default.
• W2893267975 creator A5037411420 @default.
• W2893267975 creator A5063967221 @default.
• W2893267975 creator A5064468814 @default.
• W2893267975 date "2019-01-01" @default.
• W2893267975 modified "2023-10-16" @default.
• W2893267975 title "Outcomes of Mechanical Mitral Valve Replacement in Children" @default.
• W2893267975 cites W1963749798 @default.
• W2893267975 cites W1967344786 @default.
• W2893267975 cites W2016330786 @default.
• W2893267975 cites W2021524217 @default.
• W2893267975 cites W2035112718 @default.
• W2893267975 cites W2035289646 @default.
• W2893267975 cites W2041380963 @default.
• W2893267975 cites W2074214988 @default.
• W2893267975 cites W2093391270 @default.
• W2893267975 cites W2102922451 @default.
• W2893267975 cites W2104387249 @default.
• W2893267975 cites W2120158707 @default.
• W2893267975 cites W2126102149 @default.
• W2893267975 cites W2128972563 @default.
• W2893267975 cites W2163387625 @default.
• W2893267975 cites W2466529557 @default.
• W2893267975 cites W2478382708 @default.
• W2893267975 cites W2803215142 @default.
• W2893267975 doi "https://doi.org/10.1016/j.athoracsur.2018.07.069" @default.
• W2893267975 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7288372" @default.
• W2893267975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30267694" @default.
• W2893267975 hasPublicationYear "2019" @default.
• W2893267975 type Work @default.
• W2893267975 sameAs 2893267975 @default.
• W2893267975 citedByCount "39" @default.
• W2893267975 countsByYear W28932679752019 @default.
• W2893267975 countsByYear W28932679752020 @default.
• W2893267975 countsByYear W28932679752021 @default.
• W2893267975 countsByYear W28932679752022 @default.
• W2893267975 countsByYear W28932679752023 @default.
• W2893267975 crossrefType "journal-article" @default.
• W2893267975 hasAuthorship W2893267975A5010118231 @default.
• W2893267975 hasAuthorship W2893267975A5012797487 @default.
• W2893267975 hasAuthorship W2893267975A5014402173 @default.
• W2893267975 hasAuthorship W2893267975A5018345253 @default.
• W2893267975 hasAuthorship W2893267975A5020335308 @default.
• W2893267975 hasAuthorship W2893267975A5029393460 @default.
• W2893267975 hasAuthorship W2893267975A5031664133 @default.
• W2893267975 hasAuthorship W2893267975A5033267892 @default.
• W2893267975 hasAuthorship W2893267975A5037411420 @default.
• W2893267975 hasAuthorship W2893267975A5063967221 @default.
• W2893267975 hasAuthorship W2893267975A5064468814 @default.
• W2893267975 hasBestOaLocation W28932679751 @default.
• W2893267975 hasConcept C119060515 @default.
• W2893267975 hasConcept C126322002 @default.
• W2893267975 hasConcept C141071460 @default.
• W2893267975 hasConcept C156957248 @default.
• W2893267975 hasConcept C164705383 @default.
• W2893267975 hasConcept C187212893 @default.
• W2893267975 hasConcept C207103383 @default.
• W2893267975 hasConcept C2775854548 @default.
• W2893267975 hasConcept C2777543888 @default.
• W2893267975 hasConcept C2777654188 @default.
• W2893267975 hasConcept C2911091166 @default.
• W2893267975 hasConcept C44249647 @default.
• W2893267975 hasConcept C71924100 @default.
• W2893267975 hasConceptScore W2893267975C119060515 @default.
• W2893267975 hasConceptScore W2893267975C126322002 @default.
• W2893267975 hasConceptScore W2893267975C141071460 @default.
• W2893267975 hasConceptScore W2893267975C156957248 @default.
• W2893267975 hasConceptScore W2893267975C164705383 @default.
• W2893267975 hasConceptScore W2893267975C187212893 @default.
• W2893267975 hasConceptScore W2893267975C207103383 @default.
• W2893267975 hasConceptScore W2893267975C2775854548 @default.
• W2893267975 hasConceptScore W2893267975C2777543888 @default.
• W2893267975 hasConceptScore W2893267975C2777654188 @default.
• W2893267975 hasConceptScore W2893267975C2911091166 @default.
• W2893267975 hasConceptScore W2893267975C44249647 @default.
• W2893267975 hasConceptScore W2893267975C71924100 @default.
• W2893267975 hasFunder F4320337338 @default.
• W2893267975 hasIssue "1" @default.
• W2893267975 hasLocation W28932679751 @default.
• W2893267975 hasLocation W28932679752 @default.
• W2893267975 hasLocation W28932679753 @default.
• W2893267975 hasLocation W28932679754 @default.
• W2893267975 hasOpenAccess W2893267975 @default.
• W2893267975 hasPrimaryLocation W28932679751 @default.
• W2893267975 hasRelatedWork W1951029148 @default.
• W2893267975 hasRelatedWork W2106118893 @default.
• W2893267975 hasRelatedWork W2240094448 @default.
• W2893267975 hasRelatedWork W2519173878 @default.
• W2893267975 hasRelatedWork W2896706741 @default.

• next