Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893271207> ?p ?o ?g. }
- W2893271207 abstract "Abstract The intermediate filament protein nestin is expressed during embryonic development, but considered largely restricted to areas of regeneration in the adult. Here, we perform a body-wide transcriptome and protein-profiling analysis to reveal that nestin is constitutively, and highly-selectively, expressed in adult human endothelial cells (EC), independent of proliferative status. Correspondingly, we demonstrate that it is not a marker for tumour EC in multiple malignancy types. Imaging of EC from different vascular beds reveals nestin subcellular distribution is shear-modulated. siRNA inhibition of nestin increases EC proliferation, and nestin expression is reduced in atherosclerotic plaque neovessels. eQTL analysis reveals an association between SNPs linked to cardiovascular disease and reduced aortic EC nestin mRNA expression. Our study challenges the dogma that nestin is a marker of proliferation, and provides insight into its regulation and function in EC. Furthermore, our systems-based approach can be applied to investigate body-wide expression profiles of any candidate protein." @default.
- W2893271207 created "2018-10-05" @default.
- W2893271207 creator A5011635059 @default.
- W2893271207 creator A5021112720 @default.
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- W2893271207 creator A5041800520 @default.
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- W2893271207 creator A5067640431 @default.
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- W2893271207 creator A5070950600 @default.
- W2893271207 creator A5080838497 @default.
- W2893271207 creator A5084280756 @default.
- W2893271207 date "2018-10-02" @default.
- W2893271207 modified "2023-10-15" @default.
- W2893271207 title "A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein" @default.
- W2893271207 cites W1533942137 @default.
- W2893271207 cites W158459298 @default.
- W2893271207 cites W1967296654 @default.
- W2893271207 cites W1969353942 @default.
- W2893271207 cites W1977539993 @default.
- W2893271207 cites W1977818394 @default.
- W2893271207 cites W1979182907 @default.
- W2893271207 cites W1979494208 @default.
- W2893271207 cites W1985936786 @default.
- W2893271207 cites W1987145582 @default.
- W2893271207 cites W1994603761 @default.
- W2893271207 cites W1996136286 @default.
- W2893271207 cites W1997309422 @default.
- W2893271207 cites W2012034410 @default.
- W2893271207 cites W2015434397 @default.
- W2893271207 cites W2019710924 @default.
- W2893271207 cites W2019713906 @default.
- W2893271207 cites W2020593381 @default.
- W2893271207 cites W2021565823 @default.
- W2893271207 cites W2023290311 @default.
- W2893271207 cites W2027113588 @default.
- W2893271207 cites W2027645065 @default.
- W2893271207 cites W2029470215 @default.
- W2893271207 cites W2031096972 @default.
- W2893271207 cites W2038843049 @default.
- W2893271207 cites W2040081530 @default.
- W2893271207 cites W2040817842 @default.
- W2893271207 cites W2041617965 @default.
- W2893271207 cites W2043834555 @default.
- W2893271207 cites W2047175022 @default.
- W2893271207 cites W2050370340 @default.
- W2893271207 cites W2052753918 @default.
- W2893271207 cites W2053938092 @default.
- W2893271207 cites W2054612901 @default.
- W2893271207 cites W2056198219 @default.
- W2893271207 cites W2062141905 @default.
- W2893271207 cites W2063568492 @default.
- W2893271207 cites W2063703948 @default.
- W2893271207 cites W2067605157 @default.
- W2893271207 cites W2077505983 @default.
- W2893271207 cites W2081504673 @default.
- W2893271207 cites W2082641686 @default.
- W2893271207 cites W2090219633 @default.
- W2893271207 cites W2096796354 @default.
- W2893271207 cites W2102089332 @default.
- W2893271207 cites W2103017472 @default.
- W2893271207 cites W2104082168 @default.
- W2893271207 cites W2104230351 @default.
- W2893271207 cites W2105995473 @default.
- W2893271207 cites W2106924998 @default.
- W2893271207 cites W2107561896 @default.
- W2893271207 cites W2109963121 @default.
- W2893271207 cites W2115662076 @default.
- W2893271207 cites W2117119768 @default.
- W2893271207 cites W2117312496 @default.
- W2893271207 cites W2123577868 @default.
- W2893271207 cites W2124021558 @default.
- W2893271207 cites W2124143346 @default.
- W2893271207 cites W2125558267 @default.
- W2893271207 cites W2127772444 @default.
- W2893271207 cites W2127878701 @default.
- W2893271207 cites W2140729960 @default.
- W2893271207 cites W2140948660 @default.
- W2893271207 cites W2141458291 @default.
- W2893271207 cites W2143233844 @default.
- W2893271207 cites W2144705128 @default.
- W2893271207 cites W2150382963 @default.
- W2893271207 cites W2151425315 @default.
- W2893271207 cites W2153361366 @default.
- W2893271207 cites W2154194150 @default.
- W2893271207 cites W2163556487 @default.
- W2893271207 cites W2164142213 @default.
- W2893271207 cites W2165531231 @default.
- W2893271207 cites W2165582566 @default.
- W2893271207 cites W2165821488 @default.
- W2893271207 cites W2167279371 @default.
- W2893271207 cites W2169170199 @default.
- W2893271207 cites W2185522313 @default.
- W2893271207 cites W2226515601 @default.
- W2893271207 cites W2235619360 @default.
- W2893271207 cites W2258425976 @default.
- W2893271207 cites W2268232665 @default.
- W2893271207 cites W2295332190 @default.
- W2893271207 cites W2298054275 @default.