Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893278511> ?p ?o ?g. }
- W2893278511 abstract "In order to limit the adverse effects of excessive inflammation, anti-inflammatory responses are stimulated at an early stage of an infection, but during sepsis these can lead to deactivation of immune cells including monocytes. In addition, there is emerging evidence that the up-regulation of mitochondrial quality control mechanisms, including mitochondrial biogenesis and mitophagy, is important during the recovery from sepsis and inflammation. We aimed to describe the relationship between the compensatory immune and mitochondrial responses that are triggered following exposure to an inflammatory stimulus in human monocytic cells. Incubation with lipopolysaccharide resulted in a reversible change in the immune phenotype of THP-1 cells consistent with the induction of endotoxin tolerance, similar to that seen in deactivated septic monocytes. After exposure to LPS there was also early evidence of oxidative stress, which resolved in association with the induction of antioxidant defences and the stimulation of mitochondrial degradation through mitophagy. This was compensated by a parallel up-regulation of mitochondrial biogenesis that resulted in an overall increase in mitochondrial respiratory activity. These observations improve our understanding of the normal homeostatic responses that limit the adverse cellular effects of unregulated inflammation, and which may become ineffective when an infection causes sepsis." @default.
- W2893278511 created "2018-10-05" @default.
- W2893278511 creator A5007596087 @default.
- W2893278511 creator A5013583757 @default.
- W2893278511 creator A5042615970 @default.
- W2893278511 creator A5051351228 @default.
- W2893278511 creator A5065850265 @default.
- W2893278511 creator A5066839106 @default.
- W2893278511 creator A5068016588 @default.
- W2893278511 creator A5082755088 @default.
- W2893278511 creator A5083408558 @default.
- W2893278511 creator A5088297667 @default.
- W2893278511 date "2018-09-27" @default.
- W2893278511 modified "2023-10-18" @default.
- W2893278511 title "Exposure of Monocytic Cells to Lipopolysaccharide Induces Coordinated Endotoxin Tolerance, Mitochondrial Biogenesis, Mitophagy, and Antioxidant Defenses" @default.
- W2893278511 cites W1515247384 @default.
- W2893278511 cites W1834782762 @default.
- W2893278511 cites W1867360977 @default.
- W2893278511 cites W1964807436 @default.
- W2893278511 cites W1965361671 @default.
- W2893278511 cites W1968408636 @default.
- W2893278511 cites W1968432606 @default.
- W2893278511 cites W1972348350 @default.
- W2893278511 cites W1976277034 @default.
- W2893278511 cites W1983495786 @default.
- W2893278511 cites W1983691837 @default.
- W2893278511 cites W1983832155 @default.
- W2893278511 cites W1984068087 @default.
- W2893278511 cites W1985538633 @default.
- W2893278511 cites W1993197717 @default.
- W2893278511 cites W2005948700 @default.
- W2893278511 cites W2011524264 @default.
- W2893278511 cites W2013158621 @default.
- W2893278511 cites W2015883024 @default.
- W2893278511 cites W2019488837 @default.
- W2893278511 cites W2025102413 @default.
- W2893278511 cites W2025856366 @default.
- W2893278511 cites W2028288720 @default.
- W2893278511 cites W2028677517 @default.
- W2893278511 cites W2030591331 @default.
- W2893278511 cites W2034388777 @default.
- W2893278511 cites W2038976751 @default.
- W2893278511 cites W2040642611 @default.
- W2893278511 cites W2042102929 @default.
- W2893278511 cites W2044745267 @default.
- W2893278511 cites W2045821670 @default.
- W2893278511 cites W2046237540 @default.
- W2893278511 cites W2047923753 @default.
- W2893278511 cites W2048935707 @default.
- W2893278511 cites W2051932976 @default.
- W2893278511 cites W2054172399 @default.
- W2893278511 cites W2055801667 @default.
- W2893278511 cites W2057529688 @default.
- W2893278511 cites W2062450447 @default.
- W2893278511 cites W2062671133 @default.
- W2893278511 cites W2064341136 @default.
- W2893278511 cites W2072207999 @default.
- W2893278511 cites W2093558980 @default.
- W2893278511 cites W2094272082 @default.
- W2893278511 cites W2097476575 @default.
- W2893278511 cites W2103441770 @default.
- W2893278511 cites W2104221035 @default.
- W2893278511 cites W2105731567 @default.
- W2893278511 cites W2108234281 @default.
- W2893278511 cites W2109992258 @default.
- W2893278511 cites W2112900633 @default.
- W2893278511 cites W2112960996 @default.
- W2893278511 cites W2113010696 @default.
- W2893278511 cites W2113686534 @default.
- W2893278511 cites W2116568220 @default.
- W2893278511 cites W2120444833 @default.
- W2893278511 cites W2122628753 @default.
- W2893278511 cites W2124059797 @default.
- W2893278511 cites W2124105006 @default.
- W2893278511 cites W2125870353 @default.
- W2893278511 cites W2133037534 @default.
- W2893278511 cites W2134219545 @default.
- W2893278511 cites W2135154985 @default.
- W2893278511 cites W2137727168 @default.
- W2893278511 cites W2139871065 @default.
- W2893278511 cites W2147383865 @default.
- W2893278511 cites W2147425799 @default.
- W2893278511 cites W2155943701 @default.
- W2893278511 cites W2160827160 @default.
- W2893278511 cites W2161815151 @default.
- W2893278511 cites W2170228248 @default.
- W2893278511 cites W2280404143 @default.
- W2893278511 cites W2341087784 @default.
- W2893278511 cites W2470789902 @default.
- W2893278511 cites W2530424978 @default.
- W2893278511 cites W2531249461 @default.
- W2893278511 cites W2620130112 @default.
- W2893278511 cites W2626120438 @default.
- W2893278511 cites W2766287142 @default.
- W2893278511 cites W2805457715 @default.
- W2893278511 cites W4210652211 @default.
- W2893278511 cites W4251965613 @default.
- W2893278511 doi "https://doi.org/10.3389/fimmu.2018.02217" @default.
- W2893278511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6170658" @default.
- W2893278511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30319656" @default.