FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893282386> ?p ?o ?g. }

• W2893282386 endingPage "104.e15" @default.
• W2893282386 startingPage "104.e1" @default.
• W2893282386 abstract "Diagnosis of fetal heart failure depends primarily on fetal ultrasonography assessment. Our recent study demonstrated that plasma natriuretic peptide levels in umbilical cord blood were correlated with the severity of heart failure in fetuses with congenital heart defects or arrhythmias. However, percutaneous umbilical blood sampling is an invasive procedure, and therefore, less or noninvasive biomarkers reflecting fetal heart failure are required.The aim of this study was to investigate the possibility of whether maternal serum biomarkers can diagnose fetal heart failure in fetuses with congenital heart defects or arrhythmias.This exploratory cross-sectional study was conducted at a tertiary pediatric cardiac center. A total of 50 singletons with fetal congenital heart defects or arrhythmias and 50 controls who were registered in the National Cerebral and Cardiovascular Center Biobank from 2013 to 2016 were included. Maternal serum samples obtained during the third trimester were analyzed for 2 hormones and 36 cytokines using the Bio-Plex Pro Human Cancer Biomarker panels 1 and 2. We comprehensively analyzed the association between maternal serum biomarkers and ultrasonography findings or fetal arrhythmia status. Fetal heart failure was defined as a cardiovascular profile score ≤7.Of 37 fetuses with congenital heart defects, heart failure was found in 1 case of tricuspid valve dysplasia with moderate tricuspid regurgitation. Of 13 fetuses with arrhythmias, 5 had heart failure at 28-33 weeks of gestation. Maternal serum cytokine and hormone concentrations were compared between patients with and without fetal heart failure at 28-33 weeks of gestation (n = 6 and n = 61, respectively). Sixty-one fetuses without heart failure consisted of 10 with congenital heart defect, 6 with arrhythmia, and 45 controls. Maternal serum concentrations of tumor necrosis factor-α, interleukin-6, soluble Fas ligand, transforming growth factor-α, and vascular endothelial growth factor-D were significantly higher when fetuses had heart failure than when they did not (P < .05), whereas maternal serum concentrations of heparin-binding epidermal growth factor-like growth factor were significantly lower when fetuses had heart failure than when they did not (P < .05). Multivariate analysis showed that maternal serum concentrations of tumor necrosis factor-α, vascular endothelial growth factor-D, and heparin-binding epidermal growth factor-like growth factor were independently associated with fetal heart failure. The cutoff values were as follows: tumor necrosis factor-α, 68 pg/mL (sensitivity of 50.0%, specificity of 93.4%, positive likelihood ratio of 7.6, negative likelihood ratio of 0.5); vascular endothelial growth factor-D, 1156 pg/mL (sensitivity of 50.0%, specificity of 93.4%, positive likelihood ratio of 7.6, negative likelihood ratio of 0.5); and heparin-binding epidermal growth factor-like growth factor, 90 pg/mL (sensitivity of 83.3%, specificity of 83.6%, positive likelihood ratio of 5.1, negative likelihood ratio of 0.2). The combination of these 3 cytokines showed sensitivity of 100%, specificity of 80.3%, positive likelihood ratio of 5.1, and negative likelihood ratio of 0. In the absence of fetal heart failure, concentrations of all maternal serum cytokines and hormones were similar in cases of fetal congenital heart defects and controls, while maternal serum soluble CD40 ligand concentrations were increased only in fetal arrhythmias.Maternal serum concentrations of tumor necrosis factor-α, vascular endothelial growth factor-D, and heparin-binding epidermal growth factor-like growth factor were associated with fetal heart failure." @default.
• W2893282386 created "2018-10-05" @default.
• W2893282386 creator A5009697572 @default.
• W2893282386 creator A5022570191 @default.
• W2893282386 creator A5023178862 @default.
• W2893282386 creator A5026562247 @default.
• W2893282386 creator A5050241636 @default.
• W2893282386 creator A5065615472 @default.
• W2893282386 creator A5068354355 @default.
• W2893282386 creator A5069400219 @default.
• W2893282386 creator A5082727375 @default.
• W2893282386 date "2019-01-01" @default.
• W2893282386 modified "2023-10-04" @default.
• W2893282386 title "Maternal biomarkers for fetal heart failure in fetuses with congenital heart defects or arrhythmias" @default.
• W2893282386 cites W126384489 @default.
• W2893282386 cites W1492212171 @default.
• W2893282386 cites W1922557230 @default.
• W2893282386 cites W1980686214 @default.
• W2893282386 cites W1983137347 @default.
• W2893282386 cites W1985682364 @default.
• W2893282386 cites W2006095352 @default.
• W2893282386 cites W2008620680 @default.
• W2893282386 cites W2014128014 @default.
• W2893282386 cites W2073371406 @default.
• W2893282386 cites W2086267154 @default.
• W2893282386 cites W2100994529 @default.
• W2893282386 cites W2101616031 @default.
• W2893282386 cites W2148597937 @default.
• W2893282386 cites W2155826303 @default.
• W2893282386 cites W2168227730 @default.
• W2893282386 cites W2216404441 @default.
• W2893282386 cites W2557965685 @default.
• W2893282386 cites W2736321542 @default.
• W2893282386 cites W2738565700 @default.
• W2893282386 cites W2761644518 @default.
• W2893282386 cites W2790251179 @default.
• W2893282386 doi "https://doi.org/10.1016/j.ajog.2018.09.024" @default.
• W2893282386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30273582" @default.
• W2893282386 hasPublicationYear "2019" @default.
• W2893282386 type Work @default.
• W2893282386 sameAs 2893282386 @default.
• W2893282386 citedByCount "12" @default.
• W2893282386 countsByYear W28932823862018 @default.
• W2893282386 countsByYear W28932823862019 @default.
• W2893282386 countsByYear W28932823862020 @default.
• W2893282386 countsByYear W28932823862021 @default.
• W2893282386 countsByYear W28932823862022 @default.
• W2893282386 countsByYear W28932823862023 @default.
• W2893282386 crossrefType "journal-article" @default.
• W2893282386 hasAuthorship W2893282386A5009697572 @default.
• W2893282386 hasAuthorship W2893282386A5022570191 @default.
• W2893282386 hasAuthorship W2893282386A5023178862 @default.
• W2893282386 hasAuthorship W2893282386A5026562247 @default.
• W2893282386 hasAuthorship W2893282386A5050241636 @default.
• W2893282386 hasAuthorship W2893282386A5065615472 @default.
• W2893282386 hasAuthorship W2893282386A5068354355 @default.
• W2893282386 hasAuthorship W2893282386A5069400219 @default.
• W2893282386 hasAuthorship W2893282386A5082727375 @default.
• W2893282386 hasBestOaLocation W28932823861 @default.
• W2893282386 hasConcept C105702510 @default.
• W2893282386 hasConcept C126322002 @default.
• W2893282386 hasConcept C164705383 @default.
• W2893282386 hasConcept C172680121 @default.
• W2893282386 hasConcept C2776955114 @default.
• W2893282386 hasConcept C2777162553 @default.
• W2893282386 hasConcept C2778198053 @default.
• W2893282386 hasConcept C2778258057 @default.
• W2893282386 hasConcept C2779234561 @default.
• W2893282386 hasConcept C54355233 @default.
• W2893282386 hasConcept C71924100 @default.
• W2893282386 hasConcept C86803240 @default.
• W2893282386 hasConceptScore W2893282386C105702510 @default.
• W2893282386 hasConceptScore W2893282386C126322002 @default.
• W2893282386 hasConceptScore W2893282386C164705383 @default.
• W2893282386 hasConceptScore W2893282386C172680121 @default.
• W2893282386 hasConceptScore W2893282386C2776955114 @default.
• W2893282386 hasConceptScore W2893282386C2777162553 @default.
• W2893282386 hasConceptScore W2893282386C2778198053 @default.
• W2893282386 hasConceptScore W2893282386C2778258057 @default.
• W2893282386 hasConceptScore W2893282386C2779234561 @default.
• W2893282386 hasConceptScore W2893282386C54355233 @default.
• W2893282386 hasConceptScore W2893282386C71924100 @default.
• W2893282386 hasConceptScore W2893282386C86803240 @default.
• W2893282386 hasIssue "1" @default.
• W2893282386 hasLocation W28932823861 @default.
• W2893282386 hasLocation W28932823862 @default.
• W2893282386 hasOpenAccess W2893282386 @default.
• W2893282386 hasPrimaryLocation W28932823861 @default.
• W2893282386 hasRelatedWork W1491055865 @default.
• W2893282386 hasRelatedWork W2012241433 @default.
• W2893282386 hasRelatedWork W2039995053 @default.
• W2893282386 hasRelatedWork W2051712573 @default.
• W2893282386 hasRelatedWork W2076843464 @default.
• W2893282386 hasRelatedWork W2487150375 @default.
• W2893282386 hasRelatedWork W2606295083 @default.
• W2893282386 hasRelatedWork W2806210973 @default.
• W2893282386 hasRelatedWork W4247718175 @default.
• W2893282386 hasRelatedWork W4321457778 @default.

• next