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- W2893283410 abstract "Özet Deneysel epilepsi modellerinde ve epilepsi hastalarında yapılan klinik çalışmalar sonucunda, nöroinflamasyonun epilepsi patofizyolojisinde etkin bir rolü olduğuna dair önemli kanıtlar elde edilmiştir. Özellikle, nöroinflamasyonla ilişkili yolaklar ve mediyatörlerin epileptogenez sürecindeki etkisi yoğun araştırma konusu olmuş, antiepileptojenik tedavilerin ve epileptojenik biyobelirteçlerin geliştirilebilmesi için bu süreçlerin aydınlatılması önem kazanmıştır. Bu çalışmalar sonucunda birçok patofizyolojik süreç incelenmiş ve antiepileptojenik tedavi hedefleri tanımlanmıştır. Bu derlemede epileptogenez sürecinde nöroinflamasyon ile ilişkili başlıca mekanizmalar ele alınmış, antiepileptojenik tedavi geliştirilmesi odaklı olarak potansiyel hedefler gözden geçirilmiştir.Abstract Research in experimental epilepsy models and clinical investigations on epilepsy patients have provided important evidence that neuroinflammation has an effective role in epilepsy pathophysiology. Particularly, the effects of neuroinflammation-related pathways and mediators in the epileptogenesis process have been the subject of intensive research, and the elucidation of these processes has become important for the development of antiepileptogenic therapies and epileptogenic biomarkers. As a result of these studies, many pathophysiological processes have been determined and antiepileptogenic therapeutic targets have been defined. In this review, the main mechanisms involved in neuroinflammation in the epileptogenesis process are addressed and potential targets are reviewed focusing on developing antiepileptogenic therapy." @default.
- W2893283410 created "2018-10-05" @default.
- W2893283410 creator A5063019046 @default.
- W2893283410 date "2018-08-01" @default.
- W2893283410 modified "2023-10-05" @default.
- W2893283410 title "Nöroinflamasyonun Epileptogenezdeki Rolü ve Antiepileptojenik Tedavide Nöroinflamasyona Yönelik Hedefler" @default.
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- W2893283410 doi "https://doi.org/10.22312/sdusbed.421087" @default.
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