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- W289328668 abstract "Publisher Summary This chapter reviews the physiological and pathological studies in autoradiographic determination of local cerebral glucose metabolism. A number of factors influence the resolution of autoradiography. These include section thickness, film emulsion type, thickness of anti-abrasive coat on the emulsion, power of the isotope, and movement of tracer during section preparation. However, studies indicate that the film is not the resolution-limiting factor; the images on a variety of films are similar although some films produce a grainier image than do other films. It did not address the loss in resolution because of any diffusion of the isotope prior to the production of the autoradiogram. By examining autoradiograms from brain sections in a similar manner to the analysis of the grating images, Gallistel and Nichols conclude that the diffusion of the isotope may be the resolution-limiting factor as the sharpest transition they found in their brain images was a factor of 6 less steep than the transitions in the images of the gratings. The very sharp images obtained with 3 H-labeled 2-deoxyglucose autoradiography using dipping emulsions, in which the tissue is not thawed suggest that diffusion may occur during the thawing process. The development of the ‘ 14 C’ deoxyglucose technique for the measurement of local cerebral glucose metabolism has provided a powerful tool for understanding the functional organization of the central nervous system and the derangements that occur in pathological states." @default.
- W289328668 created "2016-06-24" @default.
- W289328668 creator A5029550133 @default.
- W289328668 creator A5057044065 @default.
- W289328668 date "1983-01-01" @default.
- W289328668 modified "2023-10-16" @default.
- W289328668 title "Autoradiographic Determination of Local Cerebral Glucose Metabolism: Physiological and Pathological Studies" @default.
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