Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893286836> ?p ?o ?g. }
- W2893286836 endingPage "2911" @default.
- W2893286836 startingPage "2911" @default.
- W2893286836 abstract "Cytokine interleukin 33 (IL-33) is constitutively expressed by epithelial barrier cells, and promotes the development of humoral immune responses. Along with other proinflammatory mediators released by the epithelium of airways and lungs, it plays an important role in a number of respiratory pathologies. In particular, IL-33 significantly contributes to pathogenesis of allergy and asthma; genetic variations in the IL33 locus are associated with increased susceptibility to asthma. Large-scale genome-wide association studies have identified minor “G” allele of the single-nucleotide polymorphism rs928413, located in the IL33 promoter area, as a susceptible variant for early childhood and atopic asthma development. Here, we demonstrate that the rs928413(G) allele creates a binding site for the cAMP response element-binding protein 1 (CREB1) transcription factor. In a pulmonary epithelial cell line, activation of CREB1, presumably via the p38 mitogen-activated protein kinases (MAPK) cascade, activates the IL33 promoter containing the rs928413(G) allele specifically and in a CREB1-dependent manner. This mechanism may explain the negative effect of the rs928413 minor “G” allele on asthma development." @default.
- W2893286836 created "2018-10-05" @default.
- W2893286836 creator A5047578698 @default.
- W2893286836 creator A5058435508 @default.
- W2893286836 creator A5065822531 @default.
- W2893286836 creator A5072787952 @default.
- W2893286836 date "2018-09-25" @default.
- W2893286836 modified "2023-10-16" @default.
- W2893286836 title "The Risk G Allele of the Single-Nucleotide Polymorphism rs928413 Creates a CREB1-Binding Site That Activates IL33 Promoter in Lung Epithelial Cells" @default.
- W2893286836 cites W1494282279 @default.
- W2893286836 cites W1515271856 @default.
- W2893286836 cites W1516022962 @default.
- W2893286836 cites W1557045026 @default.
- W2893286836 cites W1575966267 @default.
- W2893286836 cites W1577872659 @default.
- W2893286836 cites W1594012971 @default.
- W2893286836 cites W1747499909 @default.
- W2893286836 cites W1902360293 @default.
- W2893286836 cites W1966908189 @default.
- W2893286836 cites W1969740624 @default.
- W2893286836 cites W1972940632 @default.
- W2893286836 cites W1983312277 @default.
- W2893286836 cites W1984708466 @default.
- W2893286836 cites W1986176487 @default.
- W2893286836 cites W1987044793 @default.
- W2893286836 cites W1998100955 @default.
- W2893286836 cites W2013329696 @default.
- W2893286836 cites W2019562149 @default.
- W2893286836 cites W2024334393 @default.
- W2893286836 cites W2025662587 @default.
- W2893286836 cites W2027694148 @default.
- W2893286836 cites W2036961282 @default.
- W2893286836 cites W2037877578 @default.
- W2893286836 cites W2040166126 @default.
- W2893286836 cites W2043398720 @default.
- W2893286836 cites W2044798842 @default.
- W2893286836 cites W2045766469 @default.
- W2893286836 cites W2049672602 @default.
- W2893286836 cites W2052474826 @default.
- W2893286836 cites W2057199361 @default.
- W2893286836 cites W2057438669 @default.
- W2893286836 cites W2058065781 @default.
- W2893286836 cites W2069935301 @default.
- W2893286836 cites W2079778462 @default.
- W2893286836 cites W2080725704 @default.
- W2893286836 cites W2082624887 @default.
- W2893286836 cites W2089627898 @default.
- W2893286836 cites W2091264505 @default.
- W2893286836 cites W2092646329 @default.
- W2893286836 cites W2096539359 @default.
- W2893286836 cites W2100908574 @default.
- W2893286836 cites W2101664092 @default.
- W2893286836 cites W2108552046 @default.
- W2893286836 cites W2110253595 @default.
- W2893286836 cites W2110955240 @default.
- W2893286836 cites W2112847075 @default.
- W2893286836 cites W2116135404 @default.
- W2893286836 cites W2119141400 @default.
- W2893286836 cites W2123445833 @default.
- W2893286836 cites W2127124250 @default.
- W2893286836 cites W2132247162 @default.
- W2893286836 cites W2135599949 @default.
- W2893286836 cites W2137385309 @default.
- W2893286836 cites W2140206763 @default.
- W2893286836 cites W2152039403 @default.
- W2893286836 cites W2153273235 @default.
- W2893286836 cites W2155216218 @default.
- W2893286836 cites W2155432151 @default.
- W2893286836 cites W2156168515 @default.
- W2893286836 cites W2157710399 @default.
- W2893286836 cites W2158206794 @default.
- W2893286836 cites W2160213796 @default.
- W2893286836 cites W2162008808 @default.
- W2893286836 cites W2165277651 @default.
- W2893286836 cites W2168863365 @default.
- W2893286836 cites W2339103386 @default.
- W2893286836 cites W2372307315 @default.
- W2893286836 cites W2551492280 @default.
- W2893286836 cites W2553340044 @default.
- W2893286836 cites W2592373261 @default.
- W2893286836 cites W2605219304 @default.
- W2893286836 cites W2746600415 @default.
- W2893286836 cites W2767624705 @default.
- W2893286836 cites W2790498644 @default.
- W2893286836 cites W2827149549 @default.
- W2893286836 cites W329772223 @default.
- W2893286836 doi "https://doi.org/10.3390/ijms19102911" @default.
- W2893286836 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6212888" @default.
- W2893286836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30257479" @default.
- W2893286836 hasPublicationYear "2018" @default.
- W2893286836 type Work @default.
- W2893286836 sameAs 2893286836 @default.
- W2893286836 citedByCount "17" @default.
- W2893286836 countsByYear W28932868362018 @default.
- W2893286836 countsByYear W28932868362019 @default.
- W2893286836 countsByYear W28932868362020 @default.
- W2893286836 countsByYear W28932868362021 @default.
- W2893286836 countsByYear W28932868362022 @default.