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• W2893301364 abstract "Significance HIV creates a persistent reservoir, which is largely resistant to current antiretroviral treatment aimed at inhibiting HIV replication. CD4 + T memory lymphocytes, key components of this reservoir, are generally refractory to infection, but stimulation with γc-chain cytokines, such as IL-15, renders these cells more susceptible to HIV. We found that, by inducing cell cycle entry of CD4 + T cells, JAK1 is a key mediator responsible for counteracting the antiviral activity of SAM domain and HD domain-containing protein 1 (SAMHD1). Pharmacological inhibition of these kinases resulted in restoration of SAMHD1 in CD4 + T cells. Protecting these cells during the critical IL-15 surge observed during primary infection has the potential to limit reservoir establishment." @default.
• W2893301364 created "2018-10-05" @default.
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• W2893301364 date "2018-09-26" @default.
• W2893301364 modified "2023-10-15" @default.
• W2893301364 title "IL-15 regulates susceptibility of CD4 ⁺ T cells to HIV infection" @default.
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• W2893301364 doi "https://doi.org/10.1073/pnas.1806695115" @default.
• W2893301364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6187195" @default.
• W2893301364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30257946" @default.
• W2893301364 hasPublicationYear "2018" @default.
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