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- W2893305891 endingPage "358" @default.
- W2893305891 startingPage "358" @default.
- W2893305891 abstract "The tumor microenvironment for epithelial ovarian cancer is complex and rich in bioactive molecules that modulate cell-cell interactions and stimulate numerous signal transduction cascades. These signals ultimately modulate all aspects of tumor behavior including progression, metastasis and therapeutic response. Many of the signaling pathways converge on the small GTPase Ras-related C3 botulinum toxin substrate (Rac)1. In addition to regulating actin cytoskeleton remodeling necessary for tumor cell adhesion, migration and invasion, Rac1 through its downstream effectors, regulates cancer cell survival, tumor angiogenesis, phenotypic plasticity, quiescence, and resistance to therapeutics. In this review we discuss evidence for Rac1 activation within the ovarian tumor microenvironment, mechanisms of Rac1 dysregulation as they apply to ovarian cancer, and the potential benefits of targeting aberrant Rac1 activity in this disease. The potential for Rac1 contribution to extraperitoneal dissemination of ovarian cancer is addressed." @default.
- W2893305891 created "2018-10-05" @default.
- W2893305891 creator A5033289907 @default.
- W2893305891 creator A5035799012 @default.
- W2893305891 creator A5037432090 @default.
- W2893305891 creator A5044838085 @default.
- W2893305891 creator A5055790068 @default.
- W2893305891 date "2018-09-27" @default.
- W2893305891 modified "2023-10-14" @default.
- W2893305891 title "Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase" @default.
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