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- W2893307622 abstract "Summary statement This article highlights several molecular mechanisms that result in the assembly of integrin αVβ5-containing flat clathrin lattices in human keratinocytes. Abstract The family of integrin transmembrane receptors is essential for the normal function of multicellular organisms by facilitating cell-extracellular matrix adhesion. The vitronectin-binding integrin αVβ5 localizes to focal adhesions (FAs) as well as poorly characterized flat clathrin lattices (FCLs). Here we show that in human keratinocytes αVβ5 is predominant found in FCLs and that formation of the αVβ5-containing FCLs requires the presence of vitronectin as ligand, calcium, and the clathrin adaptor proteins ARH, Numb, and EPS15/EPS15L1. Integrin chimeras, containing the extracellular and transmembrane domains of β5 and the cytoplasmic domains of β1 or β3, almost exclusively localize in FAs. Interestingly, lowering actomyosin-mediated contractility promotes integrin redistribution to FLCs in an integrin tail-dependent manner, while increasing cellular tension favors αVβ5 clustering in FAs. Our findings strongly indicate that clustering of integrin αVβ5 in FCLs is dictated by the β5 subunit cytoplasmic domain, cellular tension, and recruitment of specific adaptor proteins to the β5 subunit cytoplasmic domains." @default.
- W2893307622 created "2018-10-05" @default.
- W2893307622 creator A5003272986 @default.
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- W2893307622 creator A5077577302 @default.
- W2893307622 date "2018-09-26" @default.
- W2893307622 modified "2023-10-02" @default.
- W2893307622 title "Mechanisms of integrin αVβ5 clustering in flat clathrin lattices" @default.
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- W2893307622 cites W1577857859 @default.
- W2893307622 cites W1594121967 @default.
- W2893307622 cites W1595132971 @default.
- W2893307622 cites W1969309483 @default.
- W2893307622 cites W1969430572 @default.
- W2893307622 cites W1970269849 @default.
- W2893307622 cites W1974096298 @default.
- W2893307622 cites W1974777081 @default.
- W2893307622 cites W1976432358 @default.
- W2893307622 cites W1977731456 @default.
- W2893307622 cites W1986292788 @default.
- W2893307622 cites W1988113468 @default.
- W2893307622 cites W1990883677 @default.
- W2893307622 cites W1991011809 @default.
- W2893307622 cites W1997140657 @default.
- W2893307622 cites W1999794993 @default.
- W2893307622 cites W2011761299 @default.
- W2893307622 cites W2013248580 @default.
- W2893307622 cites W2013381560 @default.
- W2893307622 cites W2025765361 @default.
- W2893307622 cites W2027869188 @default.
- W2893307622 cites W2034992352 @default.
- W2893307622 cites W2047623759 @default.
- W2893307622 cites W2048305477 @default.
- W2893307622 cites W2049718632 @default.
- W2893307622 cites W2051813451 @default.
- W2893307622 cites W2053731167 @default.
- W2893307622 cites W2054297426 @default.
- W2893307622 cites W2063186096 @default.
- W2893307622 cites W2064815984 @default.
- W2893307622 cites W2068585362 @default.
- W2893307622 cites W2072508525 @default.
- W2893307622 cites W2075492377 @default.
- W2893307622 cites W2081121052 @default.
- W2893307622 cites W2087898777 @default.
- W2893307622 cites W2098847901 @default.
- W2893307622 cites W2099540110 @default.
- W2893307622 cites W2101244168 @default.
- W2893307622 cites W2103891506 @default.
- W2893307622 cites W2105707485 @default.
- W2893307622 cites W2114727451 @default.
- W2893307622 cites W2116670265 @default.
- W2893307622 cites W2117697996 @default.
- W2893307622 cites W2120504118 @default.
- W2893307622 cites W2124733101 @default.
- W2893307622 cites W2128073840 @default.
- W2893307622 cites W2136405876 @default.
- W2893307622 cites W2136509538 @default.
- W2893307622 cites W2139086163 @default.
- W2893307622 cites W2139943177 @default.
- W2893307622 cites W2142608526 @default.
- W2893307622 cites W2149873896 @default.
- W2893307622 cites W2152741987 @default.
- W2893307622 cites W2153371646 @default.
- W2893307622 cites W2162982642 @default.
- W2893307622 cites W2167279371 @default.
- W2893307622 cites W2170776626 @default.
- W2893307622 cites W2174686320 @default.
- W2893307622 cites W2183883881 @default.
- W2893307622 cites W2183894717 @default.
- W2893307622 cites W2263829954 @default.
- W2893307622 cites W2315700162 @default.
- W2893307622 cites W2316278724 @default.
- W2893307622 cites W2346331532 @default.
- W2893307622 cites W2463195069 @default.
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- W2893307622 cites W2734774356 @default.
- W2893307622 cites W2737110471 @default.
- W2893307622 cites W2793567263 @default.
- W2893307622 cites W3189920043 @default.
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- W2893307622 doi "https://doi.org/10.1101/427112" @default.
- W2893307622 hasPublicationYear "2018" @default.
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