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• W2893311053 abstract "The well-known platelet shape change is the universal hallmark of activation. This review uncovers the biophysics underlying this rapid and dramatic transformation. We aim to give a broad vision of the interplay between different cytoskeletal subsystems, which is based on physical considerations and recent advances in mathematics and computational biology. These novel findings lead to the understanding that the ring of microtubules counterbalances cortical tension in the resting platelet, making it a mechanically charged system. Platelet activation breaks the balance via several mechanisms, triggering rapid ring buckling and cell rounding. Based on the review of known data concerning the relations between platelet shape and function, we hypothesize that disk-to-sphere transformation facilitates platelet adhesion under flow. Conclusions of the paper may be useful for the development of novel, cytoskeletal-based strategies of antiplatelet therapy." @default.
• W2893311053 created "2018-10-05" @default.
• W2893311053 creator A5019144370 @default.
• W2893311053 creator A5064747565 @default.
• W2893311053 date "2018-09-25" @default.
• W2893311053 modified "2023-09-24" @default.
• W2893311053 title "The platelet shape change: biophysical basis and physiological consequences" @default.
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• W2893311053 doi "https://doi.org/10.1080/09537104.2018.1514109" @default.
• W2893311053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30252574" @default.
• W2893311053 hasPublicationYear "2018" @default.
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