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- W2893315022 abstract "目的 研究硒对镉暴露小鼠肝脏转录因子(Nrf2)表达的影响及其保护作用的机制.方法 60只ICR小鼠随机分为5组,对照组采用去离子水灌胃(10ml/kg),镉暴露组用氯化镉(7 mg/kg)灌胃,硒处理组分别采用不同浓度的亚硒酸钠(0.05、0.1、0.2 mg/kg)灌胃后用氯化镉(7 mg/kg)灌胃,30 d后颈椎脱臼处死.光镜下观察肝脏形态学变化,测定血清谷丙转氨酶(ALT)和血清谷草转氨酶(AST)、肝匀浆超氧化物歧化酶(SOD)、丙二醛(MDA)、活性氧(ROS),蛋白印迹法(Western blot)检测肝脏Nrf2表达水平.结果 光镜观察镉暴露组小鼠肝脏结构形态有明显损伤,而硒处理组(0.2 mg/kg)小鼠肝脏形态损伤不明显.镉暴露组AST、ALT、MDA、ROS均高于对照组,有统计学意义(P＜0.05),硒处理组(0.2 mg/kg) AST、MDA、ROS低于单独镉暴露组,差异有统计学意义(P＜0.05).镉暴露组和硒处理组肝脏Nrf2的表达量均高于对照组,其中硒处理组Nrf2 (0.1、0.2 mg/kg)的表达量明显高于镉暴露组(P＜0.05).结论 硒可通过抑制ROS和上调Nrf2蛋白表达,对镉暴露小鼠肝脏的氧化损伤具有保护作用." @default.
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- W2893315022 date "2016-01-01" @default.
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- W2893315022 title "Protection of selenium on cadmium-induced hepatic oxidative damage via activating Nrf2 in the mice" @default.
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