FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893320044> ?p ?o ?g. }

• W2893320044 abstract "Abstract Background Exercise induces plasticity in the hippocampus, which includes increases in neurogenesis, the proliferation of new neurons, and angiogenesis, the sprouting of new capillaries from preexisting blood vessels. Following exercise, astrocytes also undergo morphological changes that parallel the events occurring in the neurovascular system. Interestingly, there have also been reports of apoptosis in the hippocampus following aerobic exercise. This experiment aimed to identify which population of hippocampal cells undergoes apoptosis after an acute bout of exercise. Methods Cleaved caspase‐3, a terminal protein in the apoptotic cascade, was initially used to identify apoptotic cells in the hippocampus after rats completed an acute bout of exercise. Next, the proportion of immature neurons, adult neurons, astrocytes, or radial glia‐like cells expressing cleaved caspase‐3 was quantified. TUNEL staining was completed as a second measure of apoptosis. Results Following exercise, cleaved caspase‐3 expression was increased in the CA1 and DG regions of the hippocampus. Cleaved caspase‐3 was not highly expressed in neuronal populations, and expression was not increased in these cells postexercise. Instead, cleaved caspase‐3 was predominantly expressed in astrocytes. Following exercise, there was an increased number of cleaved caspase‐3 positive astrocytes in DG and CA1, and cleaved caspase‐3 positive radial glia‐like cells located in the subgranular zone. To determine whether cleaved caspase‐3 expression in these glial cells was associated with apoptosis, a TUNEL assay was completed. TUNEL staining was negligible in all groups and did not mirror the pattern of caspase‐3 labeling. Conclusions Cleaved caspase‐3 expression was detected largely in non‐neuronal cell populations, and the pattern of cleaved caspase‐3 expression did not match that of TUNEL. This suggests that after exercise, cleaved caspase‐3 expression may serve a nonapoptotic role in these hippocampal astrocytes and radial glia‐like cells. It will be important to identify the function of exercise‐induced cleaved caspase‐3 expression in the future experiments." @default.
• W2893320044 created "2018-10-05" @default.
• W2893320044 creator A5006950411 @default.
• W2893320044 creator A5007850452 @default.
• W2893320044 creator A5042634527 @default.
• W2893320044 date "2018-09-21" @default.
• W2893320044 modified "2023-10-14" @default.
• W2893320044 title "Astrocytes and radial glia-like cells, but not neurons, display a nonapoptotic increase in caspase-3 expression following exercise" @default.
• W2893320044 cites W1580910258 @default.
• W2893320044 cites W1592706250 @default.
• W2893320044 cites W1601934261 @default.
• W2893320044 cites W1878441061 @default.
• W2893320044 cites W1959902108 @default.
• W2893320044 cites W1965521454 @default.
• W2893320044 cites W1966538379 @default.
• W2893320044 cites W1970672886 @default.
• W2893320044 cites W1976150153 @default.
• W2893320044 cites W1977709892 @default.
• W2893320044 cites W1978757999 @default.
• W2893320044 cites W1982850249 @default.
• W2893320044 cites W1984118219 @default.
• W2893320044 cites W1984328054 @default.
• W2893320044 cites W1987476753 @default.
• W2893320044 cites W1989049076 @default.
• W2893320044 cites W1991000015 @default.
• W2893320044 cites W1991384397 @default.
• W2893320044 cites W1995188451 @default.
• W2893320044 cites W1996449226 @default.
• W2893320044 cites W1998027578 @default.
• W2893320044 cites W2002745904 @default.
• W2893320044 cites W2012522816 @default.
• W2893320044 cites W2018029391 @default.
• W2893320044 cites W2019353207 @default.
• W2893320044 cites W2019461187 @default.
• W2893320044 cites W2021834203 @default.
• W2893320044 cites W2025374367 @default.
• W2893320044 cites W2030682942 @default.
• W2893320044 cites W2032235027 @default.
• W2893320044 cites W2040554717 @default.
• W2893320044 cites W2046046960 @default.
• W2893320044 cites W2049107885 @default.
• W2893320044 cites W2050996473 @default.
• W2893320044 cites W2052705542 @default.
• W2893320044 cites W2062017234 @default.
• W2893320044 cites W2062240162 @default.
• W2893320044 cites W2066192511 @default.
• W2893320044 cites W2070155357 @default.
• W2893320044 cites W2070476787 @default.
• W2893320044 cites W2070665737 @default.
• W2893320044 cites W2071122929 @default.
• W2893320044 cites W2073404970 @default.
• W2893320044 cites W2081380064 @default.
• W2893320044 cites W2083830460 @default.
• W2893320044 cites W2084406633 @default.
• W2893320044 cites W2088906043 @default.
• W2893320044 cites W2090428948 @default.
• W2893320044 cites W2098914644 @default.
• W2893320044 cites W2104281661 @default.
• W2893320044 cites W2105177783 @default.
• W2893320044 cites W2109450020 @default.
• W2893320044 cites W2117523148 @default.
• W2893320044 cites W2122162592 @default.
• W2893320044 cites W2125657871 @default.
• W2893320044 cites W2129030266 @default.
• W2893320044 cites W2130473558 @default.
• W2893320044 cites W2130568682 @default.
• W2893320044 cites W2130707752 @default.
• W2893320044 cites W2130941610 @default.
• W2893320044 cites W2131435088 @default.
• W2893320044 cites W2132504992 @default.
• W2893320044 cites W2135776824 @default.
• W2893320044 cites W2137327820 @default.
• W2893320044 cites W2138778124 @default.
• W2893320044 cites W2142771923 @default.
• W2893320044 cites W2144419601 @default.
• W2893320044 cites W2148525491 @default.
• W2893320044 cites W2154554320 @default.
• W2893320044 cites W2163234334 @default.
• W2893320044 cites W2165224884 @default.
• W2893320044 cites W2165302236 @default.
• W2893320044 cites W2165721689 @default.
• W2893320044 cites W2172266256 @default.
• W2893320044 cites W2179495678 @default.
• W2893320044 cites W2183877230 @default.
• W2893320044 cites W2224586907 @default.
• W2893320044 cites W2262705777 @default.
• W2893320044 cites W2536398251 @default.
• W2893320044 cites W2545937586 @default.
• W2893320044 cites W2609511098 @default.
• W2893320044 cites W2614673012 @default.
• W2893320044 cites W2615449285 @default.
• W2893320044 cites W2764189104 @default.
• W2893320044 cites W2768632708 @default.
• W2893320044 cites W2794687462 @default.
• W2893320044 doi "https://doi.org/10.1002/brb3.1110" @default.
• W2893320044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6192401" @default.
• W2893320044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30240148" @default.
• W2893320044 hasPublicationYear "2018" @default.
• W2893320044 type Work @default.
• W2893320044 sameAs 2893320044 @default.

• next