FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893331331> ?p ?o ?g. }

• W2893331331 endingPage "558" @default.
• W2893331331 startingPage "549" @default.
• W2893331331 abstract "Objective: We evaluated the prognostic impact of circulating tumor cells (CTCs) for patients with presumed resectable pancreatic and periampullary cancers. Summary of Background Data: Initial treatment decisions for this group are currently taken without a reliable prognostic marker. The CellSearch system allows standardized CTC-testing and has shown excellent specificity and prognostic value in other applications. Methods: Preoperative blood samples from 242 patients between September 2009 and December 2014 were analyzed. One hundred seventy-nine patients underwent tumor resection, of whom 30 with stage-I tumors and duodenal cancer were assigned to the low-risk group, and the others to the high-risk group. Further 33 had advanced disease, 30 benign histology. Observation ended in December 2016. Cancer-specific survival (CSS) and disease-free survival (DFS) were calculated by log-rank and Cox regression. Results: CTCs (CTC-positive; ≥1 CTC/7.5 mL) were detected in 6.8% (10/147) of the high-risk patients and 6.2% (2/33) with advanced disease. No CTCs (CTC-negative) were detected in the low-risk patients or benign disease. In high-risk patients, median CSS for CTC-positive versus CTC-negative was 8.1 versus 20.0 months ( P < 0.0001), and DFS 4.0 versus 10.5 months ( P < 0.001). Median CSS in advanced disease was 7.7 months. Univariate hazard ratio (HR) of CTC-positivity was 3.4 ( P < 0.001). In multivariable analysis, CTC-status remained independent (HR: 2.4, P = 0.009) when corrected for histological type (HR: 2.7, P = 0.030), nodal status (HR: 1.7, P = 0.016), and vascular infiltration (HR: 1.7, P = 0.001). Conclusion: Patients testing CTC-positive preoperatively showed a detrimental outcome despite successful tumor resections. Although the low CTC-rate seems a limiting factor, results indicate high specificity. Thus, preoperative analysis of CTCs by this test may guide treatment decisions and warrants further testing in clinical trials." @default.
• W2893331331 created "2018-10-05" @default.
• W2893331331 creator A5001565523 @default.
• W2893331331 creator A5006466096 @default.
• W2893331331 creator A5015712824 @default.
• W2893331331 creator A5019201746 @default.
• W2893331331 creator A5023254706 @default.
• W2893331331 creator A5032849503 @default.
• W2893331331 creator A5049479584 @default.
• W2893331331 creator A5053271304 @default.
• W2893331331 creator A5057843599 @default.
• W2893331331 creator A5070261051 @default.
• W2893331331 date "2020-03-01" @default.
• W2893331331 modified "2023-10-13" @default.
• W2893331331 title "Circulating Tumor Cells are an Independent Predictor of Shorter Survival in Patients Undergoing Resection for Pancreatic and Periampullary Adenocarcinoma" @default.
• W2893331331 cites W1847306764 @default.
• W2893331331 cites W1875789692 @default.
• W2893331331 cites W1917588793 @default.
• W2893331331 cites W1971589201 @default.
• W2893331331 cites W1995338489 @default.
• W2893331331 cites W2029352240 @default.
• W2893331331 cites W2029864630 @default.
• W2893331331 cites W2071665937 @default.
• W2893331331 cites W2074687081 @default.
• W2893331331 cites W2079753351 @default.
• W2893331331 cites W2086916836 @default.
• W2893331331 cites W2102198783 @default.
• W2893331331 cites W2116483002 @default.
• W2893331331 cites W2127496116 @default.
• W2893331331 cites W2129000608 @default.
• W2893331331 cites W2132317169 @default.
• W2893331331 cites W2146006182 @default.
• W2893331331 cites W2153011144 @default.
• W2893331331 cites W2155828430 @default.
• W2893331331 cites W2159070981 @default.
• W2893331331 cites W2169632044 @default.
• W2893331331 cites W2171237493 @default.
• W2893331331 cites W2227942525 @default.
• W2893331331 cites W2233161210 @default.
• W2893331331 cites W2412485289 @default.
• W2893331331 cites W2467479187 @default.
• W2893331331 cites W2566484518 @default.
• W2893331331 cites W2581973599 @default.
• W2893331331 cites W2588758007 @default.
• W2893331331 cites W2591565495 @default.
• W2893331331 cites W2606624379 @default.
• W2893331331 cites W2732893441 @default.
• W2893331331 cites W2737050117 @default.
• W2893331331 cites W2743061229 @default.
• W2893331331 cites W2754884944 @default.
• W2893331331 cites W2761846603 @default.
• W2893331331 cites W2790097008 @default.
• W2893331331 cites W2796752297 @default.
• W2893331331 cites W838548246 @default.
• W2893331331 doi "https://doi.org/10.1097/sla.0000000000003035" @default.
• W2893331331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30216219" @default.
• W2893331331 hasPublicationYear "2020" @default.
• W2893331331 type Work @default.
• W2893331331 sameAs 2893331331 @default.
• W2893331331 citedByCount "35" @default.
• W2893331331 countsByYear W28933313312018 @default.
• W2893331331 countsByYear W28933313312019 @default.
• W2893331331 countsByYear W28933313312020 @default.
• W2893331331 countsByYear W28933313312021 @default.
• W2893331331 countsByYear W28933313312022 @default.
• W2893331331 countsByYear W28933313312023 @default.
• W2893331331 crossrefType "journal-article" @default.
• W2893331331 hasAuthorship W2893331331A5001565523 @default.
• W2893331331 hasAuthorship W2893331331A5006466096 @default.
• W2893331331 hasAuthorship W2893331331A5015712824 @default.
• W2893331331 hasAuthorship W2893331331A5019201746 @default.
• W2893331331 hasAuthorship W2893331331A5023254706 @default.
• W2893331331 hasAuthorship W2893331331A5032849503 @default.
• W2893331331 hasAuthorship W2893331331A5049479584 @default.
• W2893331331 hasAuthorship W2893331331A5053271304 @default.
• W2893331331 hasAuthorship W2893331331A5057843599 @default.
• W2893331331 hasAuthorship W2893331331A5070261051 @default.
• W2893331331 hasConcept C121608353 @default.
• W2893331331 hasConcept C126322002 @default.
• W2893331331 hasConcept C143998085 @default.
• W2893331331 hasConcept C144301174 @default.
• W2893331331 hasConcept C146357865 @default.
• W2893331331 hasConcept C151730666 @default.
• W2893331331 hasConcept C207103383 @default.
• W2893331331 hasConcept C2779013556 @default.
• W2893331331 hasConcept C2780210213 @default.
• W2893331331 hasConcept C2781182431 @default.
• W2893331331 hasConcept C2909874672 @default.
• W2893331331 hasConcept C38180746 @default.
• W2893331331 hasConcept C44249647 @default.
• W2893331331 hasConcept C50382708 @default.
• W2893331331 hasConcept C61238886 @default.
• W2893331331 hasConcept C71924100 @default.
• W2893331331 hasConcept C86803240 @default.
• W2893331331 hasConcept C90924648 @default.
• W2893331331 hasConceptScore W2893331331C121608353 @default.
• W2893331331 hasConceptScore W2893331331C126322002 @default.
• W2893331331 hasConceptScore W2893331331C143998085 @default.

• next