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- W2893332042 endingPage "220" @default.
- W2893332042 startingPage "193" @default.
- W2893332042 abstract "After completing the growth phase in preovulatory follicles, oocytes remain arrested in meiotic prophase and are incompetent for fertilization. Upon gonadotropin stimulation, a subpopulation of oocytes reenters meiosis and complete nuclear maturation. At the same time, they undergo major, but poorly delineated, molecular and organelle remodeling, a process that is termed “cytoplasmic maturation” and is necessary to generate an egg competent for embryo development. Establishment of this developmental competence takes place in the absence of transcription and relies entirely on the translation of mRNAs transcribed earlier during growth. A large class of RNA-binding proteins (RBPs), often unique to the oocyte, orchestrates this program of maternal mRNA unmasking, translation, and degradation. Thus, translational regulations are indispensable for progression through meiosis and nuclear maturation as well as for assembling the machinery required for transition to a totipotent cell. Elucidating the molecular details of translational control in oocytes is crucial to understanding female infertility, defects in embryonic development, and other human pathologies linked to defective gene expression, such as cancer. Here, we will review the components and major functions associated with translational regulation of maternal mRNAs in the oocytes and summarize the principles and functional significance of these regulations." @default.
- W2893332042 created "2018-10-05" @default.
- W2893332042 creator A5073141644 @default.
- W2893332042 creator A5084562124 @default.
- W2893332042 date "2019-01-01" @default.
- W2893332042 modified "2023-10-18" @default.
- W2893332042 title "RNA Binding Protein Networks and Translational Regulation in Oocytes" @default.
- W2893332042 cites W126837237 @default.
- W2893332042 cites W139064901 @default.
- W2893332042 cites W1531632576 @default.
- W2893332042 cites W1842452185 @default.
- W2893332042 cites W1945781468 @default.
- W2893332042 cites W1966711656 @default.
- W2893332042 cites W1967280237 @default.
- W2893332042 cites W1967312115 @default.
- W2893332042 cites W1967751241 @default.
- W2893332042 cites W1970561408 @default.
- W2893332042 cites W1971564824 @default.
- W2893332042 cites W1972175499 @default.
- W2893332042 cites W1972942136 @default.
- W2893332042 cites W1973397682 @default.
- W2893332042 cites W1974676736 @default.
- W2893332042 cites W1977528107 @default.
- W2893332042 cites W1978326437 @default.
- W2893332042 cites W1980084095 @default.
- W2893332042 cites W1983479039 @default.
- W2893332042 cites W1983651061 @default.
- W2893332042 cites W1984249881 @default.
- W2893332042 cites W1985963348 @default.
- W2893332042 cites W1986468286 @default.
- W2893332042 cites W1986630370 @default.
- W2893332042 cites W1986988560 @default.
- W2893332042 cites W1990375473 @default.
- W2893332042 cites W1991807334 @default.
- W2893332042 cites W1991978196 @default.
- W2893332042 cites W1993079403 @default.
- W2893332042 cites W1995165455 @default.
- W2893332042 cites W2003263870 @default.
- W2893332042 cites W2004046421 @default.
- W2893332042 cites W2013561680 @default.
- W2893332042 cites W2015298443 @default.
- W2893332042 cites W2021190535 @default.
- W2893332042 cites W2021708105 @default.
- W2893332042 cites W2021848169 @default.
- W2893332042 cites W2022121903 @default.
- W2893332042 cites W2022582257 @default.
- W2893332042 cites W2022770379 @default.
- W2893332042 cites W2025708369 @default.
- W2893332042 cites W2025811871 @default.
- W2893332042 cites W2027872555 @default.
- W2893332042 cites W2030892205 @default.
- W2893332042 cites W2031416354 @default.
- W2893332042 cites W2031707270 @default.
- W2893332042 cites W2032483955 @default.
- W2893332042 cites W2034117623 @default.
- W2893332042 cites W2035098976 @default.
- W2893332042 cites W2035905798 @default.
- W2893332042 cites W2036373513 @default.
- W2893332042 cites W2037437212 @default.
- W2893332042 cites W2039772754 @default.
- W2893332042 cites W2040306681 @default.
- W2893332042 cites W2041440237 @default.
- W2893332042 cites W2041647540 @default.
- W2893332042 cites W2041689291 @default.
- W2893332042 cites W2042868184 @default.
- W2893332042 cites W2043572640 @default.
- W2893332042 cites W2046919826 @default.
- W2893332042 cites W2048929274 @default.
- W2893332042 cites W2049175933 @default.
- W2893332042 cites W2051701405 @default.
- W2893332042 cites W2054167608 @default.
- W2893332042 cites W2055624537 @default.
- W2893332042 cites W2055930249 @default.
- W2893332042 cites W2056555106 @default.
- W2893332042 cites W2056685629 @default.
- W2893332042 cites W2057844875 @default.
- W2893332042 cites W2060265196 @default.
- W2893332042 cites W2060275204 @default.
- W2893332042 cites W2060608189 @default.
- W2893332042 cites W2061428016 @default.
- W2893332042 cites W2065305930 @default.
- W2893332042 cites W2065651113 @default.
- W2893332042 cites W2069215557 @default.
- W2893332042 cites W2071103790 @default.
- W2893332042 cites W2071424220 @default.
- W2893332042 cites W2072338652 @default.
- W2893332042 cites W2076241697 @default.
- W2893332042 cites W2079921190 @default.
- W2893332042 cites W2085643090 @default.
- W2893332042 cites W2087173922 @default.
- W2893332042 cites W2087465471 @default.
- W2893332042 cites W2088708165 @default.
- W2893332042 cites W2091235283 @default.
- W2893332042 cites W2091724447 @default.
- W2893332042 cites W2093071388 @default.
- W2893332042 cites W2094746916 @default.
- W2893332042 cites W2095849729 @default.
- W2893332042 cites W2097184870 @default.