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- W2893336591 endingPage "2481" @default.
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- W2893336591 abstract "Abstract Microglial cells are one of the interstitial elements of the pineal gland (PG). We recently reported the pattern of microglia colonization and activation, and microglia‐Pax6 + cell interactions during normal pineal ontogeny. Here, we describe the dynamics of microglia‐Pax6 + cell associations and interactions after surgical or pharmacological manipulation. In adult rats, the superior cervical ganglia (SCG) were exposed, and either bilaterally excised (SCGx) or decentralized (SCGd). In the SCGx PGs, the density of Iba1 + microglia increased after surgery and returned to sham baseline levels 13 days later. Pineal microglia also responded to SCGd, a more subtle denervation. The number of clustered Iba1 + /PCNA + /ED1 + microglia was higher 4 days after both surgeries compared to the sham‐operated group. However, the number of Pax6 + /PCNA − cells and the percentage of Pax6 + cells contacted by and/or phagocytosed by microglia increased significantly only after SCGx. Separate groups of rats were treated with either bacterial lipopolysaccharides (LPS) or doxycycline (DOX) to activate or inhibit pineal microglia, respectively. Peripheral LPS administration caused an increase in the number of clustered Iba1 + /PCNA + /ED1 + microglial cells, and in the percentage of Pax6 + cells associated with and/or engulfed by microglia. In the LPS‐treated PGs, we also noted an increase in the number of PCNA + cells that were Iba1 − within the microglial cell clusters. The density of Pax6 + cells did not change after LPS treatment. DOX administration did not influence the parameters analyzed. These data suggest that pineal microglia are highly receptive cells capable of rapidly responding in a differential manner to surgical and pharmacological stimuli." @default.
- W2893336591 created "2018-10-05" @default.
- W2893336591 creator A5006603853 @default.
- W2893336591 creator A5013177125 @default.
- W2893336591 creator A5047013277 @default.
- W2893336591 creator A5054880805 @default.
- W2893336591 creator A5055061665 @default.
- W2893336591 creator A5079169518 @default.
- W2893336591 date "2018-09-24" @default.
- W2893336591 modified "2023-10-09" @default.
- W2893336591 title "Differential response of pineal microglia to surgical versus pharmacological stimuli" @default.
- W2893336591 cites W1508215685 @default.
- W2893336591 cites W1516126098 @default.
- W2893336591 cites W1569889800 @default.
- W2893336591 cites W1889154171 @default.
- W2893336591 cites W1893317083 @default.
- W2893336591 cites W1944130357 @default.
- W2893336591 cites W1965176301 @default.
- W2893336591 cites W1967318633 @default.
- W2893336591 cites W1974626393 @default.
- W2893336591 cites W1978159035 @default.
- W2893336591 cites W1980075972 @default.
- W2893336591 cites W1982224607 @default.
- W2893336591 cites W1984073377 @default.
- W2893336591 cites W1985892724 @default.
- W2893336591 cites W1991805788 @default.
- W2893336591 cites W1996024251 @default.
- W2893336591 cites W1996548918 @default.
- W2893336591 cites W1997397043 @default.
- W2893336591 cites W2008520171 @default.
- W2893336591 cites W2008810019 @default.
- W2893336591 cites W2009828929 @default.
- W2893336591 cites W2010238834 @default.
- W2893336591 cites W2014575379 @default.
- W2893336591 cites W2024859207 @default.
- W2893336591 cites W2027467386 @default.
- W2893336591 cites W2029190354 @default.
- W2893336591 cites W2031809301 @default.
- W2893336591 cites W2036717742 @default.
- W2893336591 cites W2045512359 @default.
- W2893336591 cites W2053176712 @default.
- W2893336591 cites W2055182498 @default.
- W2893336591 cites W2058593952 @default.
- W2893336591 cites W2061293090 @default.
- W2893336591 cites W2063436144 @default.
- W2893336591 cites W2067267561 @default.
- W2893336591 cites W2067311978 @default.
- W2893336591 cites W2067551275 @default.
- W2893336591 cites W2070855360 @default.
- W2893336591 cites W2071702386 @default.
- W2893336591 cites W2073078555 @default.
- W2893336591 cites W2078184977 @default.
- W2893336591 cites W2082682758 @default.
- W2893336591 cites W2085701678 @default.
- W2893336591 cites W2089426150 @default.
- W2893336591 cites W2090069168 @default.
- W2893336591 cites W2090836465 @default.
- W2893336591 cites W2091269685 @default.
- W2893336591 cites W2104431737 @default.
- W2893336591 cites W2109210857 @default.
- W2893336591 cites W2111561559 @default.
- W2893336591 cites W2112516157 @default.
- W2893336591 cites W2114843994 @default.
- W2893336591 cites W2117122511 @default.
- W2893336591 cites W2118145481 @default.
- W2893336591 cites W2122600191 @default.
- W2893336591 cites W2130767350 @default.
- W2893336591 cites W2131016140 @default.
- W2893336591 cites W2131927172 @default.
- W2893336591 cites W2132435801 @default.
- W2893336591 cites W2139778190 @default.
- W2893336591 cites W2140380746 @default.
- W2893336591 cites W2142470584 @default.
- W2893336591 cites W2146032033 @default.
- W2893336591 cites W2151293405 @default.
- W2893336591 cites W2153756807 @default.
- W2893336591 cites W2157198621 @default.
- W2893336591 cites W2161456562 @default.
- W2893336591 cites W2161687343 @default.
- W2893336591 cites W2165804706 @default.
- W2893336591 cites W2170875086 @default.
- W2893336591 cites W2181190166 @default.
- W2893336591 cites W2232460448 @default.
- W2893336591 cites W2261364877 @default.
- W2893336591 cites W2300114742 @default.
- W2893336591 cites W2314848516 @default.
- W2893336591 cites W2336534940 @default.
- W2893336591 cites W2410229905 @default.
- W2893336591 cites W2421266045 @default.
- W2893336591 cites W2497241389 @default.
- W2893336591 cites W2527645962 @default.
- W2893336591 cites W2550527679 @default.
- W2893336591 cites W2550628733 @default.
- W2893336591 cites W2586952008 @default.
- W2893336591 cites W2588897146 @default.
- W2893336591 cites W2596399728 @default.
- W2893336591 cites W2606527202 @default.
- W2893336591 cites W2611805755 @default.