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- W2893337114 abstract "Spironolactone form I melts at about 70 degrees lower than form II, which is very unusual for two co-existing polymorphs. The phase relationships involving this unprecedented case of dimorphism have been investigated by constructing a topological pressure-temperature phase diagram. The transition from polymorph I to polymorph II is unambiguously exothermic while it is accompanied with an increase in the specific volume. This indicates that the dP/dT slope of the I-II equilibrium curve is negative. The convergence of the melting equilibrium lines at high pressure leads to a topological P-T diagram in which polymorph I possesses a stable phase region at high pressure. Thus, forms I and II are monotropically related at ordinary pressure and turn to an enantiotropic relationship at high pressure. Given that polymorph I is the densest form, it negates the rule of thumb that the densest form is also the most stable form at room temperature, similar to the case of paracetamol." @default.
- W2893337114 created "2018-10-05" @default.
- W2893337114 creator A5034059238 @default.
- W2893337114 creator A5042930474 @default.
- W2893337114 creator A5044972268 @default.
- W2893337114 creator A5055425663 @default.
- W2893337114 creator A5064139616 @default.
- W2893337114 date "2018-12-01" @default.
- W2893337114 modified "2023-10-16" @default.
- W2893337114 title "Polymorphism of spironolactone: An unprecedented case of monotropy turning to enantiotropy with a huge difference in the melting temperatures" @default.
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