FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893342694> ?p ?o ?g. }

• W2893342694 endingPage "1378" @default.
• W2893342694 startingPage "1369" @default.
• W2893342694 abstract "Methamphetamine is an addictive stimulant that can cause many adverse physical, psychological and psychosocial effects. Preliminary evidence shows cannabidiol, a non-intoxicating constituent of the cannabis plant, may have efficacy in treating opioid and nicotine dependence. However, no study has yet examined whether cannabidiol treatment might impact on methamphetamine addiction.The current study investigated whether cannabidiol administration reduces the motivation to self-administer methamphetamine and relapse to methamphetamine-seeking behavior following abstinence.Thirty-two male Sprague Dawley rats with implanted jugular vein catheters were initially trained to self-administer methamphetamine via lever press during two-hour sessions on a fixed ratio 1 schedule of reinforcement. Rats in experiment 1 ( n=16) then advanced to a progressive ratio reinforcement schedule to examine the effects of cannabidiol (0, 20, 40, and 80 mg/kg intraperitoneal) on motivation to self-administer methamphetamine. Rats in experiment 2 ( n=16) were tested for cannabidiol effects on methamphetamine-primed reinstatement following extinction.Cannabidiol (80 mg/kg, but not 40 mg/kg, or 20 mg/kg) reduced the motivation to self-administer methamphetamine and attenuated methamphetamine-primed relapse to methamphetamine-seeking behavior after extinction.This is the first demonstration that cannabidiol can reduce the motivation to seek and consume methamphetamine, and suggests that cannabidiol might be worth trialing as a novel pharmacotherapy for methamphetamine dependence." @default.
• W2893342694 created "2018-10-05" @default.
• W2893342694 creator A5020515788 @default.
• W2893342694 creator A5022324222 @default.
• W2893342694 creator A5022589029 @default.
• W2893342694 creator A5023762020 @default.
• W2893342694 creator A5031782931 @default.
• W2893342694 creator A5034201027 @default.
• W2893342694 creator A5075208609 @default.
• W2893342694 creator A5076428552 @default.
• W2893342694 date "2018-09-27" @default.
• W2893342694 modified "2023-10-13" @default.
• W2893342694 title "Cannabidiol treatment reduces the motivation to self-administer methamphetamine and methamphetamine-primed relapse in rats" @default.
• W2893342694 cites W1246635139 @default.
• W2893342694 cites W1570177053 @default.
• W2893342694 cites W1632580824 @default.
• W2893342694 cites W1973088286 @default.
• W2893342694 cites W1988937453 @default.
• W2893342694 cites W1998021006 @default.
• W2893342694 cites W2011083127 @default.
• W2893342694 cites W2020825180 @default.
• W2893342694 cites W2024501939 @default.
• W2893342694 cites W2030258997 @default.
• W2893342694 cites W2030623240 @default.
• W2893342694 cites W2033728865 @default.
• W2893342694 cites W2033990205 @default.
• W2893342694 cites W2056425055 @default.
• W2893342694 cites W2056710937 @default.
• W2893342694 cites W2071924132 @default.
• W2893342694 cites W2077008768 @default.
• W2893342694 cites W2087748457 @default.
• W2893342694 cites W2091054811 @default.
• W2893342694 cites W2092885097 @default.
• W2893342694 cites W2101643484 @default.
• W2893342694 cites W2103903337 @default.
• W2893342694 cites W2105590889 @default.
• W2893342694 cites W2106232499 @default.
• W2893342694 cites W2112319950 @default.
• W2893342694 cites W2128076336 @default.
• W2893342694 cites W2142942681 @default.
• W2893342694 cites W2144602786 @default.
• W2893342694 cites W2149110258 @default.
• W2893342694 cites W2151546922 @default.
• W2893342694 cites W2161516646 @default.
• W2893342694 cites W2169269177 @default.
• W2893342694 cites W2174548557 @default.
• W2893342694 cites W2258007998 @default.
• W2893342694 cites W2520603580 @default.
• W2893342694 cites W2528865109 @default.
• W2893342694 cites W2592601290 @default.
• W2893342694 cites W2601916337 @default.
• W2893342694 cites W2620218661 @default.
• W2893342694 cites W2621296590 @default.
• W2893342694 cites W2761862301 @default.
• W2893342694 cites W2883750535 @default.
• W2893342694 doi "https://doi.org/10.1177/0269881118799954" @default.
• W2893342694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30260267" @default.
• W2893342694 hasPublicationYear "2018" @default.
• W2893342694 type Work @default.
• W2893342694 sameAs 2893342694 @default.
• W2893342694 citedByCount "54" @default.
• W2893342694 countsByYear W28933426942019 @default.
• W2893342694 countsByYear W28933426942020 @default.
• W2893342694 countsByYear W28933426942021 @default.
• W2893342694 countsByYear W28933426942022 @default.
• W2893342694 countsByYear W28933426942023 @default.
• W2893342694 crossrefType "journal-article" @default.
• W2893342694 hasAuthorship W2893342694A5020515788 @default.
• W2893342694 hasAuthorship W2893342694A5022324222 @default.
• W2893342694 hasAuthorship W2893342694A5022589029 @default.
• W2893342694 hasAuthorship W2893342694A5023762020 @default.
• W2893342694 hasAuthorship W2893342694A5031782931 @default.
• W2893342694 hasAuthorship W2893342694A5034201027 @default.
• W2893342694 hasAuthorship W2893342694A5075208609 @default.
• W2893342694 hasAuthorship W2893342694A5076428552 @default.
• W2893342694 hasConcept C101991246 @default.
• W2893342694 hasConcept C118552586 @default.
• W2893342694 hasConcept C15744967 @default.
• W2893342694 hasConcept C185592680 @default.
• W2893342694 hasConcept C199289684 @default.
• W2893342694 hasConcept C2776895053 @default.
• W2893342694 hasConcept C2777056318 @default.
• W2893342694 hasConcept C2778555786 @default.
• W2893342694 hasConcept C2780376393 @default.
• W2893342694 hasConcept C2780557958 @default.
• W2893342694 hasConcept C2780687700 @default.
• W2893342694 hasConcept C42219234 @default.
• W2893342694 hasConcept C48856860 @default.
• W2893342694 hasConcept C71924100 @default.
• W2893342694 hasConcept C98274493 @default.
• W2893342694 hasConceptScore W2893342694C101991246 @default.
• W2893342694 hasConceptScore W2893342694C118552586 @default.
• W2893342694 hasConceptScore W2893342694C15744967 @default.
• W2893342694 hasConceptScore W2893342694C185592680 @default.
• W2893342694 hasConceptScore W2893342694C199289684 @default.
• W2893342694 hasConceptScore W2893342694C2776895053 @default.
• W2893342694 hasConceptScore W2893342694C2777056318 @default.
• W2893342694 hasConceptScore W2893342694C2778555786 @default.

• next