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• W2893344246 abstract "Abstract OBJECTIVES Robust biomarkers for pancreatic cancer (PaC) early detection/prognosis are critical for improved patient survival. Our goal was to explore the biomarker potential of 5-hydroxymethylcytosines (5hmC), an epigenetic marker with a distinct role in cancer pathobiology, yet under-investigated due largely to technical constraints. METHODS We used the TAB-Array assay, a state-of-the-art technology to directly profile 5hmC at single base resolution with the Illumina EPIC array (>850,000 CpG sites) in 17 pairs of tumor/adjacent tissue samples from US patients. RESULTS We demonstrated distinctive distributions of 5hmC in tissues, and substantial differences between tumor and adjacent tissues, suggesting their diagnostic/prognostic value of for PaC. CONCLUSION This study established the potential of 5hmC as a novel epigenetic biomarker for PaC." @default.
• W2893344246 created "2018-10-05" @default.
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• W2893344246 date "2018-09-25" @default.
• W2893344246 modified "2023-09-26" @default.
• W2893344246 title "Novel 5-Hydroxymethylcytosine Markers for Pancreatic Cancer" @default.
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• W2893344246 doi "https://doi.org/10.1101/425983" @default.
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