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- W2893344314 abstract "INTRODUCTION :Hyperdynamic circulatory state is a common and long-recognized feature of patients withdecompensated chronic liver disease. It is characterized by elevated cardiac rate and output andreduced peripheral vascular resistance, with pooling of blood in the splanchnic and peripheralcirculation and effective central hypovolemia.The autonomic nervous system plays a central role in modulating cardiac performance and thevasomotor activity in the hyperdynamic circulatory state.The presence of an autonomic dysfunction (AD) in cirrhosis has been clearly shown through differentexperimental approaches, including the evaluation of the cardiovascular and sudomotor responses tophysiological and pharmacological stimulation), and by showing a hyperproduction of weakadrenergic neurotransmitters.It has also been reported that the severity of AD is proportional to the severity of cirrhosis, and itspresence is an indicator of poor prognosis in patients with both early and advanced liver disease.In an earlier study from our department, the presence of AD correlated with the occurrence of varicealbleed .Heart rate variability implies variations in the interval between consecutive heart beats as well asbetween consecutive instantaneous heart rate, ie, it describes the variations of both instantaneous heart rate and RR intervals. It is a simple test to assess the function of the autonomic nervous systemand its modulation on the heart rate.Measurement of AD in chronic liver disease, using Heart rate variability (HRV), has been shown tocorrelate with the underlying severity of the liver disease. But, there are no studies from India, onthe impact of Heart rate variability in predicting the severity, prognosis and bleed pattern in patientswith cirrhosis liver.AIM OF THE STUDY : To assess Heart rate variability (HRV) as a test for Autonomic nervous system (ANS) functionin patients with liver cirrhosis, comparing it with healthy controls. To correlate HRV results with the severity of the underlying liver disease To compare HRV outcome between – Bleeders and non-bleeders – Survivors and non-survivors.CONCLUSION : HRV analysis is a simple, noninvasive test to assess the cardiovascular autonomic function in patients with chronic liver disease.Patients with liver cirrhosis have significantly reduced heart rate variability (decreased parasympatheticactivity) and an increased sympathetic tone in supine posture.Cirrhotics have an abnormal homeostatic response to standing with no increase in sympathetic tone inthe upright posture.With worsening Child Pugh class (A vs B/C), there is an increase in autonomic dysfunction, with anincreased activity of the sympathetic component.There were no significant differences in HRV parameters between bleeders versus non-bleeders andsurvivors versus non-survivors." @default.
- W2893344314 created "2018-10-05" @default.
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- W2893344314 date "2009-08-01" @default.
- W2893344314 modified "2023-09-27" @default.
- W2893344314 title "Heart Rate Variability in Cirrhosis Liver." @default.
- W2893344314 hasPublicationYear "2009" @default.
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