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- W2893352386 endingPage "1756" @default.
- W2893352386 startingPage "1741" @default.
- W2893352386 abstract "Abstract In this review, we retrospect our progress in biological active naphthalimide and analogues as antitumor agents in the past 20 years. On one hand, various derivations in naphthalimide pharmacophores were developed to enhance their DNA binding affinity and antitumor property thereby. Heterocyclic fused naphthalimides, bis-naphthalimides, non-fused substituted naphthalimides and the carboxamide derivatives were synthesized. For example, thio-heterocyclic fused-naphthalimides were designed and evaluated in comparison with their oxo-heterocyclic fused analogues. Extended or created heterocycle-based skeleton were also developed as antitumor agents. On the other hand, we broaden the design strategy of naphthalimide antitumor agents besides DNA intercalation and topo II poison. We have introduced more drug design methods, such as prodrugs, multitarget drugs, computer-aided drug design, photodynamic therapy. For example, we have got naphthalimide derivatives which inhibited topo II and induced LMP by introducing long alkyl chain and polyamines. Several representative compounds were clarified of their antitumor mechanism of action. In all, our research improves the structure diversity of naphthalimide antitumor agents and distinct variances of antitumor targets and mechanism of action." @default.
- W2893352386 created "2018-10-05" @default.
- W2893352386 creator A5017825677 @default.
- W2893352386 creator A5027738049 @default.
- W2893352386 creator A5065472339 @default.
- W2893352386 date "2018-12-01" @default.
- W2893352386 modified "2023-09-24" @default.
- W2893352386 title "Naphthalimides and analogues as antitumor agents: A review on molecular design, bioactivity and mechanism of action" @default.
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