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- W2893358207 abstract "Significance This paper reveals the molecular logic for generating the basal methylation pattern in each individual following erasure of the gametic profile in the preimplantation embryo. The results show that transcription factors and the RNA polymerase complex play a major role in protecting recognized regions from de novo methylation by recruiting the H3K4 methylation machinery. Because methylation is stably maintained through development, this mechanism serves to perpetuate the activity state present in the early embryo. This model may also help explain how transient factors from the gametes may influence methylation patterns in the offspring and, thereby, contribute to intergenerational epigenetic inheritance." @default.
- W2893358207 created "2018-10-05" @default.
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- W2893358207 date "2018-09-26" @default.
- W2893358207 modified "2023-10-02" @default.
- W2893358207 title "Role of transcription complexes in the formation of the basal methylation pattern in early development" @default.
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- W2893358207 doi "https://doi.org/10.1073/pnas.1804755115" @default.
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