FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893359111> ?p ?o ?g. }

• W2893359111 abstract "Secondary metabolites in plants play important roles in defence against biotic and abiotic stresses. Although the biosynthesis pathways of secondary metabolites have been extensively studied, the regulatory mechanism of gene expression involved in these pathways remains poorly understood. In this study, we develop a virus-induced gene silencing (VIGS) system that enables a rapid analysis of the regulatory mechanism of genes involved in the biosynthesis of isoprenoids, one of the largest groups in secondary metabolites, using hydroponically-grown Nicotiana benthamiana. Using VIGS, we successfully reduced the transcript levels of 3-hydroxy-3-methylglutaryl-CoA reductase 1 (HMGR1), cycloartenol synthase 1 (CAS1), sterol side chain reductase 2 (SSR2) and S-adenosyl-L-Met-dependent C-24 sterol methyltransferase 1 (SMT1) in leaf, stem and root tissues in approximately 2 weeks. We identified novel feedback and feed-forward regulation of isoprenoid biosynthesis genes when CAS1, which encodes a key enzyme involved in the biosynthesis of sterols and steroidal glycoalkaloids, was down-regulated. Furthermore, the regulation of these genes differed among different tissues. These results demonstrate that our system can rapidly analyse the regulatory mechanisms involved in the biosynthesis of secondary metabolites." @default.
• W2893359111 created "2018-10-05" @default.
• W2893359111 creator A5048595030 @default.
• W2893359111 creator A5056492658 @default.
• W2893359111 creator A5080096226 @default.
• W2893359111 creator A5080724286 @default.
• W2893359111 date "2018-10-04" @default.
• W2893359111 modified "2023-09-29" @default.
• W2893359111 title "Analysis of the mechanisms regulating the expression of isoprenoid biosynthesis genes in hydroponically-grown Nicotiana benthamiana plants using virus-induced gene silencing" @default.
• W2893359111 cites W1489746883 @default.
• W2893359111 cites W1780409766 @default.
• W2893359111 cites W1928030931 @default.
• W2893359111 cites W1971430242 @default.
• W2893359111 cites W1976604018 @default.
• W2893359111 cites W1983254271 @default.
• W2893359111 cites W1987637262 @default.
• W2893359111 cites W1994997968 @default.
• W2893359111 cites W2012486473 @default.
• W2893359111 cites W2019992266 @default.
• W2893359111 cites W2021933218 @default.
• W2893359111 cites W2026468967 @default.
• W2893359111 cites W2031387028 @default.
• W2893359111 cites W2033866420 @default.
• W2893359111 cites W2044717234 @default.
• W2893359111 cites W2046861930 @default.
• W2893359111 cites W2047439748 @default.
• W2893359111 cites W2056541403 @default.
• W2893359111 cites W2060906856 @default.
• W2893359111 cites W2069932011 @default.
• W2893359111 cites W2071047395 @default.
• W2893359111 cites W2071759565 @default.
• W2893359111 cites W2081663195 @default.
• W2893359111 cites W2092053018 @default.
• W2893359111 cites W2093153708 @default.
• W2893359111 cites W2105455566 @default.
• W2893359111 cites W2116029921 @default.
• W2893359111 cites W2120867053 @default.
• W2893359111 cites W2132926880 @default.
• W2893359111 cites W2134529777 @default.
• W2893359111 cites W2134812217 @default.
• W2893359111 cites W2137905527 @default.
• W2893359111 cites W2138835651 @default.
• W2893359111 cites W2144000440 @default.
• W2893359111 cites W2161586272 @default.
• W2893359111 cites W2166142631 @default.
• W2893359111 cites W2168310063 @default.
• W2893359111 cites W2285514562 @default.
• W2893359111 cites W2307193518 @default.
• W2893359111 cites W2309929323 @default.
• W2893359111 cites W2311203695 @default.
• W2893359111 cites W2329442555 @default.
• W2893359111 cites W2419479960 @default.
• W2893359111 cites W2555341825 @default.
• W2893359111 cites W2562413738 @default.
• W2893359111 cites W2571266433 @default.
• W2893359111 cites W2598611441 @default.
• W2893359111 cites W2751514064 @default.
• W2893359111 cites W4242257733 @default.
• W2893359111 cites W4245012862 @default.
• W2893359111 cites W4294216491 @default.
• W2893359111 cites W5632706 @default.
• W2893359111 doi "https://doi.org/10.1038/s41598-018-32901-5" @default.
• W2893359111 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6172274" @default.
• W2893359111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30287831" @default.
• W2893359111 hasPublicationYear "2018" @default.
• W2893359111 type Work @default.
• W2893359111 sameAs 2893359111 @default.
• W2893359111 citedByCount "9" @default.
• W2893359111 countsByYear W28933591112020 @default.
• W2893359111 countsByYear W28933591112021 @default.
• W2893359111 countsByYear W28933591112022 @default.
• W2893359111 countsByYear W28933591112023 @default.
• W2893359111 crossrefType "journal-article" @default.
• W2893359111 hasAuthorship W2893359111A5048595030 @default.
• W2893359111 hasAuthorship W2893359111A5056492658 @default.
• W2893359111 hasAuthorship W2893359111A5080096226 @default.
• W2893359111 hasAuthorship W2893359111A5080724286 @default.
• W2893359111 hasBestOaLocation W28933591111 @default.
• W2893359111 hasConcept C104317684 @default.
• W2893359111 hasConcept C119056186 @default.
• W2893359111 hasConcept C150194340 @default.
• W2893359111 hasConcept C165864922 @default.
• W2893359111 hasConcept C2777157883 @default.
• W2893359111 hasConcept C2778761015 @default.
• W2893359111 hasConcept C2778803642 @default.
• W2893359111 hasConcept C2780562374 @default.
• W2893359111 hasConcept C553450214 @default.
• W2893359111 hasConcept C55493867 @default.
• W2893359111 hasConcept C86803240 @default.
• W2893359111 hasConcept C95444343 @default.
• W2893359111 hasConceptScore W2893359111C104317684 @default.
• W2893359111 hasConceptScore W2893359111C119056186 @default.
• W2893359111 hasConceptScore W2893359111C150194340 @default.
• W2893359111 hasConceptScore W2893359111C165864922 @default.
• W2893359111 hasConceptScore W2893359111C2777157883 @default.
• W2893359111 hasConceptScore W2893359111C2778761015 @default.
• W2893359111 hasConceptScore W2893359111C2778803642 @default.
• W2893359111 hasConceptScore W2893359111C2780562374 @default.
• W2893359111 hasConceptScore W2893359111C553450214 @default.
• W2893359111 hasConceptScore W2893359111C55493867 @default.

• next